The emerging role of glycolysis and immune evasion in ovarian cancer
Abstract Ovarian cancer (OC) is one of the three most common malignant tumors of the female reproductive system, with the highest mortality rate among gynecologic malignancies. Like other tumors, OC cells undergo metabolic reprogramming phenomenon and convert glucose metabolism into “aerobic glycoly...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-025-03698-x |
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| author | Bowen Jin Zehua Miao Junjie Pan Zhen Zhang Yibei Yang Yidong Zhou Yuanxiang Jin Zheng Niu Qiaoping Xu |
| author_facet | Bowen Jin Zehua Miao Junjie Pan Zhen Zhang Yibei Yang Yidong Zhou Yuanxiang Jin Zheng Niu Qiaoping Xu |
| author_sort | Bowen Jin |
| collection | DOAJ |
| description | Abstract Ovarian cancer (OC) is one of the three most common malignant tumors of the female reproductive system, with the highest mortality rate among gynecologic malignancies. Like other tumors, OC cells undergo metabolic reprogramming phenomenon and convert glucose metabolism into “aerobic glycolysis” and generate a high concentration of lactate, i.e., the “Warburg effect”, which provides a large amount of energy and corresponding intermediary metabolites for their survival, reproduction and metastasis. Numerous studies have shown that targeted inhibition of aerobic glycolysis and lactate metabolism is a promising strategy to enhance the sensitivity of cancer cells to immunotherapy. Therefore, this review summarizes the metabolic features of glycolysis in OC cells and highlights how abnormal lactate concentration affects the differentiation, metabolism, and function of infiltrating immune cells, which contributes to immunosuppression, and how targeted inhibition of this phenomenon may be a potential strategy to enhance the therapeutic efficacy of OC. |
| format | Article |
| id | doaj-art-a8463a6c851b4be7bb0d49f6249085ba |
| institution | DOAJ |
| issn | 1475-2867 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-a8463a6c851b4be7bb0d49f6249085ba2025-08-20T03:05:49ZengBMCCancer Cell International1475-28672025-03-0125111810.1186/s12935-025-03698-xThe emerging role of glycolysis and immune evasion in ovarian cancerBowen Jin0Zehua Miao1Junjie Pan2Zhen Zhang3Yibei Yang4Yidong Zhou5Yuanxiang Jin6Zheng Niu7Qiaoping Xu8Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Cancer Center, Westlake University School of MedicineDalian Medical UniversityFourth Clinical Medical College of Zhejiang Chinese Medical UniversityDepartment of Oncology, Hangzhou Cancer HospitalFourth Clinical Medical College of Zhejiang Chinese Medical UniversityFourth Clinical Medical College of Zhejiang Chinese Medical UniversityFourth Clinical Medical College of Zhejiang Chinese Medical UniversityDepartment of Gynecology, Affiliated Hangzhou First People’s Hospital, Cancer Center, Westlake University School of MedicineDepartment of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Cancer Center, Westlake University School of MedicineAbstract Ovarian cancer (OC) is one of the three most common malignant tumors of the female reproductive system, with the highest mortality rate among gynecologic malignancies. Like other tumors, OC cells undergo metabolic reprogramming phenomenon and convert glucose metabolism into “aerobic glycolysis” and generate a high concentration of lactate, i.e., the “Warburg effect”, which provides a large amount of energy and corresponding intermediary metabolites for their survival, reproduction and metastasis. Numerous studies have shown that targeted inhibition of aerobic glycolysis and lactate metabolism is a promising strategy to enhance the sensitivity of cancer cells to immunotherapy. Therefore, this review summarizes the metabolic features of glycolysis in OC cells and highlights how abnormal lactate concentration affects the differentiation, metabolism, and function of infiltrating immune cells, which contributes to immunosuppression, and how targeted inhibition of this phenomenon may be a potential strategy to enhance the therapeutic efficacy of OC.https://doi.org/10.1186/s12935-025-03698-xOvarian cancerGlycolysisMicroenvironmentImmune evasionImmunotherapy |
| spellingShingle | Bowen Jin Zehua Miao Junjie Pan Zhen Zhang Yibei Yang Yidong Zhou Yuanxiang Jin Zheng Niu Qiaoping Xu The emerging role of glycolysis and immune evasion in ovarian cancer Cancer Cell International Ovarian cancer Glycolysis Microenvironment Immune evasion Immunotherapy |
| title | The emerging role of glycolysis and immune evasion in ovarian cancer |
| title_full | The emerging role of glycolysis and immune evasion in ovarian cancer |
| title_fullStr | The emerging role of glycolysis and immune evasion in ovarian cancer |
| title_full_unstemmed | The emerging role of glycolysis and immune evasion in ovarian cancer |
| title_short | The emerging role of glycolysis and immune evasion in ovarian cancer |
| title_sort | emerging role of glycolysis and immune evasion in ovarian cancer |
| topic | Ovarian cancer Glycolysis Microenvironment Immune evasion Immunotherapy |
| url | https://doi.org/10.1186/s12935-025-03698-x |
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