Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa.
Background: Bacteriophages are viruses that are used to destroy bacteria without harming host cells. As a result, it is thought that they can be used to treat bacterial infections alone or in conjunction with antibiotics. Pseudomonas aeruginosa, a multidrug-resistant bacterial pathogen, is one of th...
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Zagazig University, Faculty of Medicine
2024-05-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_294547_52fab040cb0b17807d73c16ebebebf45.pdf |
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| author | Aravind Sasi Kavitha K Thiyagarjan sanjeevi Ravikumar Sambandam Aarthi Manoharan Aboobacker A Latha R |
| author_facet | Aravind Sasi Kavitha K Thiyagarjan sanjeevi Ravikumar Sambandam Aarthi Manoharan Aboobacker A Latha R |
| author_sort | Aravind Sasi |
| collection | DOAJ |
| description | Background: Bacteriophages are viruses that are used to destroy bacteria without harming host cells. As a result, it is thought that they can be used to treat bacterial infections alone or in conjunction with antibiotics. Pseudomonas aeruginosa, a multidrug-resistant bacterial pathogen, is one of the most prevalent infections in diabetic foot ulcers and has a high fatality rate. This bacterium produces a biofilm that causes recurring infections that are antibiotic-resistant and causes severe tissue damage with varying levels of severity. In this review, the role of bacteriophage therapy in diabetic foot ulcers, their advantages, limitation, and future perspectives will be discussed. The bacteriophage therapy to combat antibiotic-resistant bacteria is quite appealing, and some study data suggests that it could be a reasonable solution to overcome severe bacterial infections which cannot be treated by antibiotics. Some studies revealed that bacteriophage can be combined with antibiotics and used for effective treatment. However, phage therapy application in human treatment is scanty because the concurrent and underlying mechanism of this strategy is ambiguous among clinicians. Additionally, there are still problems with how to create formulas for standardized and therapeutic use in bacterial control. More study that is specifically devoted to resolving these problems is necessary before bacteriophages can be used in humans. Bacteriophage therapy will be a better choice for treating diabetic foot ulcers once everything has been cleaned up, and the incidence of amputation can be decreased by bacteriophage therapy. |
| format | Article |
| id | doaj-art-a83e0589c3ad4e5792c4ed43513e1ec5 |
| institution | Kabale University |
| issn | 2682-4132 2682-4140 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj-art-a83e0589c3ad4e5792c4ed43513e1ec52024-12-21T21:02:47ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402024-05-015261262410.21608/mid.2023.201469.1490294547Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa.Aravind Sasi0Kavitha K1Thiyagarjan sanjeevi2Ravikumar Sambandam3Aarthi Manoharan4Aboobacker A5Latha R6Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.Multi-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, IndiaMulti-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, IndiaMulti-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, IndiaDepartment of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.Background: Bacteriophages are viruses that are used to destroy bacteria without harming host cells. As a result, it is thought that they can be used to treat bacterial infections alone or in conjunction with antibiotics. Pseudomonas aeruginosa, a multidrug-resistant bacterial pathogen, is one of the most prevalent infections in diabetic foot ulcers and has a high fatality rate. This bacterium produces a biofilm that causes recurring infections that are antibiotic-resistant and causes severe tissue damage with varying levels of severity. In this review, the role of bacteriophage therapy in diabetic foot ulcers, their advantages, limitation, and future perspectives will be discussed. The bacteriophage therapy to combat antibiotic-resistant bacteria is quite appealing, and some study data suggests that it could be a reasonable solution to overcome severe bacterial infections which cannot be treated by antibiotics. Some studies revealed that bacteriophage can be combined with antibiotics and used for effective treatment. However, phage therapy application in human treatment is scanty because the concurrent and underlying mechanism of this strategy is ambiguous among clinicians. Additionally, there are still problems with how to create formulas for standardized and therapeutic use in bacterial control. More study that is specifically devoted to resolving these problems is necessary before bacteriophages can be used in humans. Bacteriophage therapy will be a better choice for treating diabetic foot ulcers once everything has been cleaned up, and the incidence of amputation can be decreased by bacteriophage therapy.https://mid.journals.ekb.eg/article_294547_52fab040cb0b17807d73c16ebebebf45.pdfdiabetic foot ulcerbacteriophagepseudomonas aeruginosaand antibiotic resistance |
| spellingShingle | Aravind Sasi Kavitha K Thiyagarjan sanjeevi Ravikumar Sambandam Aarthi Manoharan Aboobacker A Latha R Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. Microbes and Infectious Diseases diabetic foot ulcer bacteriophage pseudomonas aeruginosa and antibiotic resistance |
| title | Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. |
| title_full | Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. |
| title_fullStr | Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. |
| title_full_unstemmed | Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. |
| title_short | Bacteriophage therapy in diabetic foot ulcer caused by Pseudomonas aeruginosa. |
| title_sort | bacteriophage therapy in diabetic foot ulcer caused by pseudomonas aeruginosa |
| topic | diabetic foot ulcer bacteriophage pseudomonas aeruginosa and antibiotic resistance |
| url | https://mid.journals.ekb.eg/article_294547_52fab040cb0b17807d73c16ebebebf45.pdf |
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