Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study
Abstract Background The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this sit...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s40359-024-02211-9 |
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| author | Majid Omari Salima Kriya Sara Nadi Ghita Zerhouni Chaymae El Abbas Achraf El Asri Zineb Benbrahim Nawfel Mellas Karima El Rhazi Mohammed El Amine Ragala Jaouad El Hilaly Karima Halim Lamiae Amaadour Btissame Zarrouq |
| author_facet | Majid Omari Salima Kriya Sara Nadi Ghita Zerhouni Chaymae El Abbas Achraf El Asri Zineb Benbrahim Nawfel Mellas Karima El Rhazi Mohammed El Amine Ragala Jaouad El Hilaly Karima Halim Lamiae Amaadour Btissame Zarrouq |
| author_sort | Majid Omari |
| collection | DOAJ |
| description | Abstract Background The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies. The aim of this study is to explore effective and ineffective psychological adjustment mobilized by Moroccan patients newly diagnosed with BC and before receiving neoadjuvant chemotherapy, as well as to identify their associations to socio-demographic and clinical determinants. Materials and methods A total of 209 patients were recruited in outpatient in oncology department in the public oncology hospital of Fez city, between 2021 and 2023. Ethics approval was obtained for this study and patients has signed an informed consent form. The questionnaire interview included socio-economic and clinical variables and the Arabic version of Mini-Mental Adjustment to Cancer (Mini-MAC) scale, which measures the strategies of mental adjustment to disease, as fighting spirit (FS), hopelessness/helplessness (HH), anxious preoccupations (AP), cognitive avoidance (CA), fatalism (FA), “maladaptive coping” and “adaptive coping”. Bivariate analysis of psychological adjustment strategies and sociodemographic and clinical variables was carried out using statistical tests according to the nature of the variables, to their normality and the homogeneity of their variances. Univariate and multivariate linear regression modelling was carried out using a forward “enter” regression procedure. Results A mean age of 47.43 ± 9.45 was found among participants. Assessment of mental adjustment to cancer using Mini-MAC scores revealed that psychological adjustment strategies with a higher mean score were FA, FS and “adaptive coping” strategies. Based mainly on multiple linear Regression, monthly family income was negatively associated with HH, and FS and positively linked to FA and “adaptive coping” strategies. Moreover, the left side as BC laterality was negatively associated with AP and “maladaptive coping” strategies. Furthermore, positive ER status was negatively associated with HH and “maladaptive coping” strategies and high Ki-67 levels were positively linked to AP. Conclusion Programs to strengthen psychological adjustment in patients with BC candidates for NACT, taking into consideration the determinants found associated in this study, are of great importance since the first oncology consultation. |
| format | Article |
| id | doaj-art-a83b59baaccb4b4bb58a24ba4d991a60 |
| institution | OA Journals |
| issn | 2050-7283 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Psychology |
| spelling | doaj-art-a83b59baaccb4b4bb58a24ba4d991a602025-08-20T02:38:35ZengBMCBMC Psychology2050-72832024-11-0112111010.1186/s40359-024-02211-9Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort studyMajid Omari0Salima Kriya1Sara Nadi2Ghita Zerhouni3Chaymae El Abbas4Achraf El Asri5Zineb Benbrahim6Nawfel Mellas7Karima El Rhazi8Mohammed El Amine Ragala9Jaouad El Hilaly10Karima Halim11Lamiae Amaadour12Btissame Zarrouq13Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityDepartment of Biology and Geology, Teacher’s Training College (Ecole Normale Supérieure), Sidi Mohamed Ben Abdallah UniversityDepartment of Biology and Geology, Teacher’s Training College (Ecole Normale Supérieure), Sidi Mohamed Ben Abdallah UniversityLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityDepartment of Medical Oncology, Hassan II University HospitalDepartment of Medical Oncology, Hassan II University HospitalLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityLaboratory of Pedagogical and Didactic Engineering of Sciences and Mathematics, Regional Center of Education and Training (CRME F) of FezLaboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah UniversityDepartment of Medical Oncology, Hassan II University HospitalLaboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah UniversityAbstract Background The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies. The aim of this study is to explore effective and ineffective psychological adjustment mobilized by Moroccan patients newly diagnosed with BC and before receiving neoadjuvant chemotherapy, as well as to identify their associations to socio-demographic and clinical determinants. Materials and methods A total of 209 patients were recruited in outpatient in oncology department in the public oncology hospital of Fez city, between 2021 and 2023. Ethics approval was obtained for this study and patients has signed an informed consent form. The questionnaire interview included socio-economic and clinical variables and the Arabic version of Mini-Mental Adjustment to Cancer (Mini-MAC) scale, which measures the strategies of mental adjustment to disease, as fighting spirit (FS), hopelessness/helplessness (HH), anxious preoccupations (AP), cognitive avoidance (CA), fatalism (FA), “maladaptive coping” and “adaptive coping”. Bivariate analysis of psychological adjustment strategies and sociodemographic and clinical variables was carried out using statistical tests according to the nature of the variables, to their normality and the homogeneity of their variances. Univariate and multivariate linear regression modelling was carried out using a forward “enter” regression procedure. Results A mean age of 47.43 ± 9.45 was found among participants. Assessment of mental adjustment to cancer using Mini-MAC scores revealed that psychological adjustment strategies with a higher mean score were FA, FS and “adaptive coping” strategies. Based mainly on multiple linear Regression, monthly family income was negatively associated with HH, and FS and positively linked to FA and “adaptive coping” strategies. Moreover, the left side as BC laterality was negatively associated with AP and “maladaptive coping” strategies. Furthermore, positive ER status was negatively associated with HH and “maladaptive coping” strategies and high Ki-67 levels were positively linked to AP. Conclusion Programs to strengthen psychological adjustment in patients with BC candidates for NACT, taking into consideration the determinants found associated in this study, are of great importance since the first oncology consultation.https://doi.org/10.1186/s40359-024-02211-9Psychological adjustmentBreast cancerNeoadjuvant chemotherapySocio-demographic determinantsClinical determinants |
| spellingShingle | Majid Omari Salima Kriya Sara Nadi Ghita Zerhouni Chaymae El Abbas Achraf El Asri Zineb Benbrahim Nawfel Mellas Karima El Rhazi Mohammed El Amine Ragala Jaouad El Hilaly Karima Halim Lamiae Amaadour Btissame Zarrouq Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study BMC Psychology Psychological adjustment Breast cancer Neoadjuvant chemotherapy Socio-demographic determinants Clinical determinants |
| title | Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study |
| title_full | Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study |
| title_fullStr | Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study |
| title_full_unstemmed | Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study |
| title_short | Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study |
| title_sort | effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy insights from a cohort study |
| topic | Psychological adjustment Breast cancer Neoadjuvant chemotherapy Socio-demographic determinants Clinical determinants |
| url | https://doi.org/10.1186/s40359-024-02211-9 |
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