From forgotten cure to modern medicine: The resurgence of bacteriophage therapy
ABSTRACT: Objectives: The unregulated use of antibiotics has led to the rise of antibiotic-resistant bacterial strains. This study explores bacteriophage therapy as an alternative treatment, highlighting its history, significance, and advancements in Europe, the United States, and the Middle East....
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524004375 |
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| author | Tasnime Abdo Ahmad Samar El Houjeiry Souha S. Kanj Ghassan M. Matar Esber S. Saba |
| author_facet | Tasnime Abdo Ahmad Samar El Houjeiry Souha S. Kanj Ghassan M. Matar Esber S. Saba |
| author_sort | Tasnime Abdo Ahmad |
| collection | DOAJ |
| description | ABSTRACT: Objectives: The unregulated use of antibiotics has led to the rise of antibiotic-resistant bacterial strains. This study explores bacteriophage therapy as an alternative treatment, highlighting its history, significance, and advancements in Europe, the United States, and the Middle East. Methods: A comprehensive literature review on bacteriophage therapy was conducted, focusing on its development, clinical trials, and patient treatment applications. The study also examined challenges, limitations, criteria for ideal phage selection, and manipulation techniques. Results: The United States and several European countries have advanced in phage therapy, progressing from clinical trials to patient treatment, whereas Middle Eastern countries are still in the early stages. Bacteriophages offer specificity, abundance, and minimal side effects, but challenges like safety concerns and potential resistance limit their widespread use. Conclusion: Bacteriophage therapy shows promise as an antibiotic alternative but faces safety and resistance challenges. Continued research and better regulatory frameworks, especially in the Middle East, are needed to realize its potential. |
| format | Article |
| id | doaj-art-a837d535f088495daebe31bb41a0c4bb |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-a837d535f088495daebe31bb41a0c4bb2025-08-20T02:39:38ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-013923123910.1016/j.jgar.2024.10.259From forgotten cure to modern medicine: The resurgence of bacteriophage therapyTasnime Abdo Ahmad0Samar El Houjeiry1Souha S. Kanj2Ghassan M. Matar3Esber S. Saba4Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut, LebanonDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut, LebanonDivision of Infectious Diseases, Department of Internal Medicine, Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, LebanonDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut, LebanonDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon; Corresponding author. Mailing address: Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut 1107 2020, Lebanon.ABSTRACT: Objectives: The unregulated use of antibiotics has led to the rise of antibiotic-resistant bacterial strains. This study explores bacteriophage therapy as an alternative treatment, highlighting its history, significance, and advancements in Europe, the United States, and the Middle East. Methods: A comprehensive literature review on bacteriophage therapy was conducted, focusing on its development, clinical trials, and patient treatment applications. The study also examined challenges, limitations, criteria for ideal phage selection, and manipulation techniques. Results: The United States and several European countries have advanced in phage therapy, progressing from clinical trials to patient treatment, whereas Middle Eastern countries are still in the early stages. Bacteriophages offer specificity, abundance, and minimal side effects, but challenges like safety concerns and potential resistance limit their widespread use. Conclusion: Bacteriophage therapy shows promise as an antibiotic alternative but faces safety and resistance challenges. Continued research and better regulatory frameworks, especially in the Middle East, are needed to realize its potential.http://www.sciencedirect.com/science/article/pii/S2213716524004375BacteriophageAntimicrobial resistanceBacteriaPhage therapy |
| spellingShingle | Tasnime Abdo Ahmad Samar El Houjeiry Souha S. Kanj Ghassan M. Matar Esber S. Saba From forgotten cure to modern medicine: The resurgence of bacteriophage therapy Journal of Global Antimicrobial Resistance Bacteriophage Antimicrobial resistance Bacteria Phage therapy |
| title | From forgotten cure to modern medicine: The resurgence of bacteriophage therapy |
| title_full | From forgotten cure to modern medicine: The resurgence of bacteriophage therapy |
| title_fullStr | From forgotten cure to modern medicine: The resurgence of bacteriophage therapy |
| title_full_unstemmed | From forgotten cure to modern medicine: The resurgence of bacteriophage therapy |
| title_short | From forgotten cure to modern medicine: The resurgence of bacteriophage therapy |
| title_sort | from forgotten cure to modern medicine the resurgence of bacteriophage therapy |
| topic | Bacteriophage Antimicrobial resistance Bacteria Phage therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524004375 |
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