Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels
Background. Cisplatin induces nephrotoxicity and this study evaluated the protective effect of fosfomycin on it in 11 gynecological cancer patients. Methods. The N‐acetyl‐β‐D‐glucosaminidase (NAG), β2‐microglobulin (β2MG), creatinine (uCr) and total protein (TP) levels in a 24‐hour urine specimen as...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-06-01
|
| Series: | Acta Obstetricia et Gynecologica Scandinavica |
| Subjects: | |
| Online Access: | https://doi.org/10.3109/00016349709024590 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850111857142005760 |
|---|---|
| author | Masatoshi Hayashi Masahide Numaguchi Hideki Watabe Hideo Enomoto Yoshimasa Yaoi |
| author_facet | Masatoshi Hayashi Masahide Numaguchi Hideki Watabe Hideo Enomoto Yoshimasa Yaoi |
| author_sort | Masatoshi Hayashi |
| collection | DOAJ |
| description | Background. Cisplatin induces nephrotoxicity and this study evaluated the protective effect of fosfomycin on it in 11 gynecological cancer patients. Methods. The N‐acetyl‐β‐D‐glucosaminidase (NAG), β2‐microglobulin (β2MG), creatinine (uCr) and total protein (TP) levels in a 24‐hour urine specimen as well as the blood urea nitrogen (BUN) and serum creatinine (sCr) were measured before and after CAPF chemotherapy alone (control) or with fosfomycin. Results. The results were statistically analyzed by using the t‐test. NAG, β2MG, uCr and TP levels increased significantly after chemotherapy in the control patients, but BUN and sCr levels did not change significantly. The NAG level in the control group was twice as high as in the fosfomycin group 8 days after chemotherapy (p<0.01). The uCr and TP in control patients increased significantly after chemotherapy when compared to those in patients coadministered fosfomycin. There were no significant changes in β2MG, BUN and sCr levels. Conclusions. Cisplatin affected the levels of NAG, β2MG, uCr and TP without influencing BUN and sCr levels. Fosfomycin, therefore, may be useful as a supplemental treatment for reducing cisplatin nephrotoxicity, especially proximal tubular damage. |
| format | Article |
| id | doaj-art-a83425adcc8540aba9d0750ef178cca5 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 1997-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-a83425adcc8540aba9d0750ef178cca52025-08-20T02:37:32ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04121997-06-0176659059510.3109/00016349709024590Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levelsMasatoshi Hayashi0Masahide Numaguchi1Hideki Watabe2Hideo Enomoto3Yoshimasa Yaoi4Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami‐Koshigaya, Koshigaya‐shi, Saitama, 343, JapanDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami‐Koshigaya, Koshigaya‐shi, Saitama, 343, JapanDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami‐Koshigaya, Koshigaya‐shi, Saitama, 343, JapanDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami‐Koshigaya, Koshigaya‐shi, Saitama, 343, JapanDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami‐Koshigaya, Koshigaya‐shi, Saitama, 343, JapanBackground. Cisplatin induces nephrotoxicity and this study evaluated the protective effect of fosfomycin on it in 11 gynecological cancer patients. Methods. The N‐acetyl‐β‐D‐glucosaminidase (NAG), β2‐microglobulin (β2MG), creatinine (uCr) and total protein (TP) levels in a 24‐hour urine specimen as well as the blood urea nitrogen (BUN) and serum creatinine (sCr) were measured before and after CAPF chemotherapy alone (control) or with fosfomycin. Results. The results were statistically analyzed by using the t‐test. NAG, β2MG, uCr and TP levels increased significantly after chemotherapy in the control patients, but BUN and sCr levels did not change significantly. The NAG level in the control group was twice as high as in the fosfomycin group 8 days after chemotherapy (p<0.01). The uCr and TP in control patients increased significantly after chemotherapy when compared to those in patients coadministered fosfomycin. There were no significant changes in β2MG, BUN and sCr levels. Conclusions. Cisplatin affected the levels of NAG, β2MG, uCr and TP without influencing BUN and sCr levels. Fosfomycin, therefore, may be useful as a supplemental treatment for reducing cisplatin nephrotoxicity, especially proximal tubular damage.https://doi.org/10.3109/00016349709024590cisplatinfosfomycinnephrotoxicityurinary metabolites |
| spellingShingle | Masatoshi Hayashi Masahide Numaguchi Hideki Watabe Hideo Enomoto Yoshimasa Yaoi Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels Acta Obstetricia et Gynecologica Scandinavica cisplatin fosfomycin nephrotoxicity urinary metabolites |
| title | Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| title_full | Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| title_fullStr | Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| title_full_unstemmed | Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| title_short | Cisplatin‐induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| title_sort | cisplatin induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels |
| topic | cisplatin fosfomycin nephrotoxicity urinary metabolites |
| url | https://doi.org/10.3109/00016349709024590 |
| work_keys_str_mv | AT masatoshihayashi cisplatininducednephrotoxicityandtheprotectiveeffectoffosfomycinonitasdemonstratedbyusingacrossoverstudyofurinarymetabolitelevels AT masahidenumaguchi cisplatininducednephrotoxicityandtheprotectiveeffectoffosfomycinonitasdemonstratedbyusingacrossoverstudyofurinarymetabolitelevels AT hidekiwatabe cisplatininducednephrotoxicityandtheprotectiveeffectoffosfomycinonitasdemonstratedbyusingacrossoverstudyofurinarymetabolitelevels AT hideoenomoto cisplatininducednephrotoxicityandtheprotectiveeffectoffosfomycinonitasdemonstratedbyusingacrossoverstudyofurinarymetabolitelevels AT yoshimasayaoi cisplatininducednephrotoxicityandtheprotectiveeffectoffosfomycinonitasdemonstratedbyusingacrossoverstudyofurinarymetabolitelevels |