Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy.

Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy.

<h4>Introduction</h4>Prostate-specific antigen (PSA) testing is a widely accepted screening method for prostate cancer, but with low specificity at thresholds giving good sensitivity. Previous research identified four single nucleotide polymorphisms (SNPs) principally associated with cir...

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Bibliographic Details
Main Authors: Rebecca Gilbert, Richard M Martin, David M Evans, Kate Tilling, George Davey Smith, John P Kemp, J Athene Lane, Freddie C Hamdy, David E Neal, Jenny L Donovan, Chris Metcalfe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0136735&type=printable
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