Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detectin...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8787261 |
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| _version_ | 1832551417112428544 |
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| author | Fengyi Wang Jiaqi Zhang Jiadan Yu Shaxin Liu Rengang Zhang Xichao Ma Yonghong Yang Pu Wang |
| author_facet | Fengyi Wang Jiaqi Zhang Jiadan Yu Shaxin Liu Rengang Zhang Xichao Ma Yonghong Yang Pu Wang |
| author_sort | Fengyi Wang |
| collection | DOAJ |
| description | Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Results. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively. Conclusions. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence. |
| format | Article |
| id | doaj-art-a83284006c4741469b89f550cf592759 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a83284006c4741469b89f550cf5927592025-02-03T06:01:35ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/87872618787261Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-AnalysisFengyi Wang0Jiaqi Zhang1Jiadan Yu2Shaxin Liu3Rengang Zhang4Xichao Ma5Yonghong Yang6Pu Wang7Rehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong KongWest China School of Medicine, Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Results. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively. Conclusions. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence.http://dx.doi.org/10.1155/2017/8787261 |
| spellingShingle | Fengyi Wang Jiaqi Zhang Jiadan Yu Shaxin Liu Rengang Zhang Xichao Ma Yonghong Yang Pu Wang Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis Journal of Diabetes Research |
| title | Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2017/8787261 |
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