Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies
Fusobacterium nucleatum (Fn), an oral anaerobic commensal, has recently been identified as a crucial oncogenic contributor to colorectal cancer pathogenesis through its ectopic colonization in the gastrointestinal tract. Accumulating evidence reveals its multifaceted involvement in colorectal cancer...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0640 |
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| author | Junna Lu Wei Wei Diwei Zheng |
| author_facet | Junna Lu Wei Wei Diwei Zheng |
| author_sort | Junna Lu |
| collection | DOAJ |
| description | Fusobacterium nucleatum (Fn), an oral anaerobic commensal, has recently been identified as a crucial oncogenic contributor to colorectal cancer pathogenesis through its ectopic colonization in the gastrointestinal tract. Accumulating evidence reveals its multifaceted involvement in colorectal cancer initiation, progression, metastasis, and therapeutic resistance to conventional treatments, including chemotherapy, radiotherapy, and immunotherapy. This perspective highlights recent advances in anti-Fn strategies, including small-molecule inhibitors, nanomedicines, and biopharmaceuticals, while critically analyzing the translational barriers in developing targeted antimicrobial interventions. We further propose potential strategies to overcome current challenges in Fn modulation, aiming to pave the way for more effective therapeutic interventions and better clinical outcomes. |
| format | Article |
| id | doaj-art-a82ef925eb1845cdb14cd49a424de3cf |
| institution | DOAJ |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-a82ef925eb1845cdb14cd49a424de3cf2025-08-20T03:06:08ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0640Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy StrategiesJunna Lu0Wei Wei1Diwei Zheng2State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.Fusobacterium nucleatum (Fn), an oral anaerobic commensal, has recently been identified as a crucial oncogenic contributor to colorectal cancer pathogenesis through its ectopic colonization in the gastrointestinal tract. Accumulating evidence reveals its multifaceted involvement in colorectal cancer initiation, progression, metastasis, and therapeutic resistance to conventional treatments, including chemotherapy, radiotherapy, and immunotherapy. This perspective highlights recent advances in anti-Fn strategies, including small-molecule inhibitors, nanomedicines, and biopharmaceuticals, while critically analyzing the translational barriers in developing targeted antimicrobial interventions. We further propose potential strategies to overcome current challenges in Fn modulation, aiming to pave the way for more effective therapeutic interventions and better clinical outcomes.https://spj.science.org/doi/10.34133/research.0640 |
| spellingShingle | Junna Lu Wei Wei Diwei Zheng Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies Research |
| title | Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies |
| title_full | Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies |
| title_fullStr | Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies |
| title_full_unstemmed | Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies |
| title_short | Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy Strategies |
| title_sort | fusobacterium nucleatum in colorectal cancer ally mechanism and targeted therapy strategies |
| url | https://spj.science.org/doi/10.34133/research.0640 |
| work_keys_str_mv | AT junnalu fusobacteriumnucleatumincolorectalcancerallymechanismandtargetedtherapystrategies AT weiwei fusobacteriumnucleatumincolorectalcancerallymechanismandtargetedtherapystrategies AT diweizheng fusobacteriumnucleatumincolorectalcancerallymechanismandtargetedtherapystrategies |