Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children
Central nervous system vasculitides in children may develop as a primary condition or secondary to an underlying systemic disease. Many vasculitides affect both adults and children, while some others occur almost exclusively in childhood. Patients usually present with systemic symptoms with single...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/698327 |
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| author | Ludovico Iannetti Roberta Zito Simone Bruschi Laura Papetti Fiorenza Ulgiati Francesco Nicita Francesca Del Balzo Alberto Spalice |
| author_facet | Ludovico Iannetti Roberta Zito Simone Bruschi Laura Papetti Fiorenza Ulgiati Francesco Nicita Francesca Del Balzo Alberto Spalice |
| author_sort | Ludovico Iannetti |
| collection | DOAJ |
| description | Central nervous system vasculitides in children may develop as a primary condition or secondary to an underlying systemic disease. Many vasculitides affect both adults and children, while some others occur almost exclusively in childhood. Patients usually present with systemic symptoms with single or multiorgan dysfunction. The involvement of central nervous system in childhood is not frequent and it occurs more often as a feature of subtypes like childhood polyarteritis nodosa, Kawasaki disease, Henoch Schönlein purpura, and Bechet disease. Primary angiitis of the central nervous system of childhood is a reversible cause of severe neurological impairment, including acute ischemic stroke, intractable seizures, and cognitive decline. The first line therapy of CNS vasculitides is mainly based on corticosteroids and immunosuppressor drugs. Other strategies include plasmapheresis, immunoglobulins, and biologic drugs. This paper discusses on current understanding of most frequent primary and secondary central nervous system vasculitides in children including a tailored-diagnostic approach and new evidence regarding treatment. |
| format | Article |
| id | doaj-art-a82d2fa67d8043708f1e8138ecd30fd9 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a82d2fa67d8043708f1e8138ecd30fd92025-08-20T02:20:45ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/698327698327Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in ChildrenLudovico Iannetti0Roberta Zito1Simone Bruschi2Laura Papetti3Fiorenza Ulgiati4Francesco Nicita5Francesca Del Balzo6Alberto Spalice7Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Pediatrics, Child Neurology Division, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Pediatrics, Child Neurology Division, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Pediatrics, Child Neurology Division, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Pediatrics, Child Neurology Division, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Pediatrics, Child Neurology Division, Sapienza University of Rome, 00185 Rome, ItalyCentral nervous system vasculitides in children may develop as a primary condition or secondary to an underlying systemic disease. Many vasculitides affect both adults and children, while some others occur almost exclusively in childhood. Patients usually present with systemic symptoms with single or multiorgan dysfunction. The involvement of central nervous system in childhood is not frequent and it occurs more often as a feature of subtypes like childhood polyarteritis nodosa, Kawasaki disease, Henoch Schönlein purpura, and Bechet disease. Primary angiitis of the central nervous system of childhood is a reversible cause of severe neurological impairment, including acute ischemic stroke, intractable seizures, and cognitive decline. The first line therapy of CNS vasculitides is mainly based on corticosteroids and immunosuppressor drugs. Other strategies include plasmapheresis, immunoglobulins, and biologic drugs. This paper discusses on current understanding of most frequent primary and secondary central nervous system vasculitides in children including a tailored-diagnostic approach and new evidence regarding treatment.http://dx.doi.org/10.1155/2012/698327 |
| spellingShingle | Ludovico Iannetti Roberta Zito Simone Bruschi Laura Papetti Fiorenza Ulgiati Francesco Nicita Francesca Del Balzo Alberto Spalice Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children Clinical and Developmental Immunology |
| title | Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children |
| title_full | Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children |
| title_fullStr | Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children |
| title_full_unstemmed | Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children |
| title_short | Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children |
| title_sort | recent understanding on diagnosis and management of central nervous system vasculitis in children |
| url | http://dx.doi.org/10.1155/2012/698327 |
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