A crucial role of miR-155 in the pathomechanism of acute kidney injury
Acute kidney injury (AKI) is one of the nonnegligible causes of mortality worldwide. It is important to understand the underlying molecular mechanism of AKI to effective therapeutic targets. miR-155 has been found to play a pivotal role in the development of AKI, while a comprehensive review on this...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1570000/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850150911431671808 |
|---|---|
| author | Hui Wang Jian Liao Wei Wang Jianhua Zhang |
| author_facet | Hui Wang Jian Liao Wei Wang Jianhua Zhang |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is one of the nonnegligible causes of mortality worldwide. It is important to understand the underlying molecular mechanism of AKI to effective therapeutic targets. miR-155 has been found to play a pivotal role in the development of AKI, while a comprehensive review on this topic is currently still lacking. Based on this review, we found that miR-155and is strongly correlated with the pathophysiological development of AKI by modulating cell apoptosis, inflammation, and proliferation. Mechanistically, miR-155 exerts a promoting function in multiple types of AKI by regulating multiple proteins or signaling pathways, such as SOCS-1, ERRFI1, SOCS-1, TRF1, CDK12, and TCF4/Wnt/β-catenin pathway. The inhibition of miR-155 has a renoprotective effect in drug- or substance-induced AKI. Therefore, drugs or biological compounds targeted by miR-155 and its pathways may recover the process of AKI by altering apoptosis, inflammation, and pyroptosis. A miRNA nanocarrier system that has already been developed could offer a novel approach to treat AKI, providing a direction for future research. Further large-scale studies are necessary to elucidate the clinical significance of miR-155 as a potential therapeutic target for multiple types of AKI. |
| format | Article |
| id | doaj-art-a82bbef50b88404d8b9ea12b3f921562 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-a82bbef50b88404d8b9ea12b3f9215622025-08-20T02:26:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15700001570000A crucial role of miR-155 in the pathomechanism of acute kidney injuryHui Wang0Jian Liao1Wei Wang2Jianhua Zhang3Department of Urology, The First People’s Hospital of Linhai, Linhai, Zhejiang, ChinaDepartment of Nephrology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, ChinaDepartment of Urology, Tiantai People’s Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People’s Hospital), Hangzhou Medical College, Taizhou, Zhejiang, ChinaDepartment of Urology, Tiantai People’s Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People’s Hospital), Hangzhou Medical College, Taizhou, Zhejiang, ChinaAcute kidney injury (AKI) is one of the nonnegligible causes of mortality worldwide. It is important to understand the underlying molecular mechanism of AKI to effective therapeutic targets. miR-155 has been found to play a pivotal role in the development of AKI, while a comprehensive review on this topic is currently still lacking. Based on this review, we found that miR-155and is strongly correlated with the pathophysiological development of AKI by modulating cell apoptosis, inflammation, and proliferation. Mechanistically, miR-155 exerts a promoting function in multiple types of AKI by regulating multiple proteins or signaling pathways, such as SOCS-1, ERRFI1, SOCS-1, TRF1, CDK12, and TCF4/Wnt/β-catenin pathway. The inhibition of miR-155 has a renoprotective effect in drug- or substance-induced AKI. Therefore, drugs or biological compounds targeted by miR-155 and its pathways may recover the process of AKI by altering apoptosis, inflammation, and pyroptosis. A miRNA nanocarrier system that has already been developed could offer a novel approach to treat AKI, providing a direction for future research. Further large-scale studies are necessary to elucidate the clinical significance of miR-155 as a potential therapeutic target for multiple types of AKI.https://www.frontiersin.org/articles/10.3389/fphar.2025.1570000/fullAKImir-155mechanismtherapeutic targetsapoptosisinflammation |
| spellingShingle | Hui Wang Jian Liao Wei Wang Jianhua Zhang A crucial role of miR-155 in the pathomechanism of acute kidney injury Frontiers in Pharmacology AKI mir-155 mechanism therapeutic targets apoptosis inflammation |
| title | A crucial role of miR-155 in the pathomechanism of acute kidney injury |
| title_full | A crucial role of miR-155 in the pathomechanism of acute kidney injury |
| title_fullStr | A crucial role of miR-155 in the pathomechanism of acute kidney injury |
| title_full_unstemmed | A crucial role of miR-155 in the pathomechanism of acute kidney injury |
| title_short | A crucial role of miR-155 in the pathomechanism of acute kidney injury |
| title_sort | crucial role of mir 155 in the pathomechanism of acute kidney injury |
| topic | AKI mir-155 mechanism therapeutic targets apoptosis inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1570000/full |
| work_keys_str_mv | AT huiwang acrucialroleofmir155inthepathomechanismofacutekidneyinjury AT jianliao acrucialroleofmir155inthepathomechanismofacutekidneyinjury AT weiwang acrucialroleofmir155inthepathomechanismofacutekidneyinjury AT jianhuazhang acrucialroleofmir155inthepathomechanismofacutekidneyinjury AT huiwang crucialroleofmir155inthepathomechanismofacutekidneyinjury AT jianliao crucialroleofmir155inthepathomechanismofacutekidneyinjury AT weiwang crucialroleofmir155inthepathomechanismofacutekidneyinjury AT jianhuazhang crucialroleofmir155inthepathomechanismofacutekidneyinjury |