A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis
Objectives: Necrotizing enterocolitis is a significant cause of morbidity and mortality in premature infants. Various fecal, urinary, and serum biomarkers have all been investigated for their potential in the prediction and early detection of necrotizing enterocolitis. This pilot study aimed to expl...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755725001184 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849229398953164800 |
|---|---|
| author | Sara Erol Cuneyt Tayman Sabriye Korkut Ufuk Çakir Abdullah Kurt Ismail Koyuncu |
| author_facet | Sara Erol Cuneyt Tayman Sabriye Korkut Ufuk Çakir Abdullah Kurt Ismail Koyuncu |
| author_sort | Sara Erol |
| collection | DOAJ |
| description | Objectives: Necrotizing enterocolitis is a significant cause of morbidity and mortality in premature infants. Various fecal, urinary, and serum biomarkers have all been investigated for their potential in the prediction and early detection of necrotizing enterocolitis. This pilot study aimed to explore the feasibility and clinical utility of measuring serum and fecal calprotectin levels in preterm infants with necrotizing enterocolitis. Methods: This prospective pilot study included preterm infants born at < 32 weeks’ gestation with a birth weight of ≤ 1500 g, consisting of patients diagnosed with necrotizing enterocolitis stage II or III and a randomly selected control group without necrotizing enterocolitis. The relationship between serum and fecal calprotectin concentrations and necrotizing enterocolitis severity, need for surgical intervention, and mortality was systematically analyzed. Results: A total of 39 necrotizing enterocolitis patients (25 with stage II, 14 with stage III) and 20 randomly selected preterm infants were included as the control group. Serum and fecal calprotectin levels were significantly higher in necrotizing enterocolitis stage III and in infants who required surgery or died (p < 0.05), indicating their potential to predict disease severity and poor outcomes. Conclusions: This pilot study suggests that dual assessment of serum and fecal calprotectin may provide insight into necrotizing enterocolitis severity and outcomes. Larger studies are needed to validate these findings and determine clinical applicability. Trial Registration: This study was registered with the ClinicalTrials.gov database under the registration number NCT06693154 on November 15, 2024. |
| format | Article |
| id | doaj-art-a81fff524ef34742adf372c969adaafd |
| institution | Kabale University |
| issn | 0021-7557 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj-art-a81fff524ef34742adf372c969adaafd2025-08-22T04:54:40ZengElsevierJornal de Pediatria0021-75572025-09-01101510142810.1016/j.jped.2025.101428A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitisSara Erol0Cuneyt Tayman1Sabriye Korkut2Ufuk Çakir3Abdullah Kurt4Ismail Koyuncu5Department of Pediatrics, Division of Neonatology, Ankara Bilkent City Hospital, Ankara, Turkey; Corresponding author.Department of Pediatrics, Division of Neonatology, Ankara Bilkent City Hospital, Ankara, TurkeyDepartment of Pediatrics, Division of Neonatology, Ankara Bilkent City Hospital, Ankara, TurkeyDepartment of Pediatrics, Division of Neonatology, Ankara Bilkent City Hospital, Ankara, TurkeyDepartment of Pediatrics, Division of Neonatology, Ankara Bilkent City Hospital, Ankara, TurkeyHarran University Faculty of Medicine, Medicinal Biochemisty, Sanliutfa, TurkeyObjectives: Necrotizing enterocolitis is a significant cause of morbidity and mortality in premature infants. Various fecal, urinary, and serum biomarkers have all been investigated for their potential in the prediction and early detection of necrotizing enterocolitis. This pilot study aimed to explore the feasibility and clinical utility of measuring serum and fecal calprotectin levels in preterm infants with necrotizing enterocolitis. Methods: This prospective pilot study included preterm infants born at < 32 weeks’ gestation with a birth weight of ≤ 1500 g, consisting of patients diagnosed with necrotizing enterocolitis stage II or III and a randomly selected control group without necrotizing enterocolitis. The relationship between serum and fecal calprotectin concentrations and necrotizing enterocolitis severity, need for surgical intervention, and mortality was systematically analyzed. Results: A total of 39 necrotizing enterocolitis patients (25 with stage II, 14 with stage III) and 20 randomly selected preterm infants were included as the control group. Serum and fecal calprotectin levels were significantly higher in necrotizing enterocolitis stage III and in infants who required surgery or died (p < 0.05), indicating their potential to predict disease severity and poor outcomes. Conclusions: This pilot study suggests that dual assessment of serum and fecal calprotectin may provide insight into necrotizing enterocolitis severity and outcomes. Larger studies are needed to validate these findings and determine clinical applicability. Trial Registration: This study was registered with the ClinicalTrials.gov database under the registration number NCT06693154 on November 15, 2024.http://www.sciencedirect.com/science/article/pii/S0021755725001184Necrotizing enterocolitisPrematurityCalprotectinPrediction |
| spellingShingle | Sara Erol Cuneyt Tayman Sabriye Korkut Ufuk Çakir Abdullah Kurt Ismail Koyuncu A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis Jornal de Pediatria Necrotizing enterocolitis Prematurity Calprotectin Prediction |
| title | A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| title_full | A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| title_fullStr | A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| title_full_unstemmed | A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| title_short | A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| title_sort | comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis |
| topic | Necrotizing enterocolitis Prematurity Calprotectin Prediction |
| url | http://www.sciencedirect.com/science/article/pii/S0021755725001184 |
| work_keys_str_mv | AT saraerol acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT cuneyttayman acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT sabriyekorkut acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT ufukcakir acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT abdullahkurt acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT ismailkoyuncu acomparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT saraerol comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT cuneyttayman comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT sabriyekorkut comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT ufukcakir comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT abdullahkurt comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis AT ismailkoyuncu comparativestudyofserumandfecalcalprotectinlevelsinnecrotizingenterocolitis |