Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

<h4>Background</h4>Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses.<h4>M...

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Bibliographic Details
Main Authors: Matthew N Davies, Jagadeesh Bayry, Elma Z Tchilian, Janakiraman Vani, Melkote S Shaila, Emily K Forbes, Simon J Draper, Peter C L Beverley, David F Tough, Darren R Flower
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008084&type=printable
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