Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases
The photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs). The function of RGCs is objectively evaluated by analysing the PhNR. We reviewed articles regarding c...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/397178 |
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| author | Shigeki Machida |
| author_facet | Shigeki Machida |
| author_sort | Shigeki Machida |
| collection | DOAJ |
| description | The photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs). The function of RGCs is objectively evaluated by analysing the PhNR. We reviewed articles regarding clinical use of the PhNR. The PhNR was well correlated with the visual sensitivity obtained by standard automated perimetry and morphometric parameters of the inner retina and optic nerve head in optic nerve and retinal diseases. Moreover, combining the PhNR with focal or multifocal ERG techniques enables the objective assessment of local function of RGCs. The PhNR is therefore likely to become established as an objective functional test for optic nerve and retinal diseases involving RGC injury. |
| format | Article |
| id | doaj-art-a80d7772b06e4aa8b6eba23103e6f2c7 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a80d7772b06e4aa8b6eba23103e6f2c72025-08-20T02:20:45ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/397178397178Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal DiseasesShigeki Machida0Department of Ophthalmology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Iwate, Morioka 020-8505, JapanThe photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs). The function of RGCs is objectively evaluated by analysing the PhNR. We reviewed articles regarding clinical use of the PhNR. The PhNR was well correlated with the visual sensitivity obtained by standard automated perimetry and morphometric parameters of the inner retina and optic nerve head in optic nerve and retinal diseases. Moreover, combining the PhNR with focal or multifocal ERG techniques enables the objective assessment of local function of RGCs. The PhNR is therefore likely to become established as an objective functional test for optic nerve and retinal diseases involving RGC injury.http://dx.doi.org/10.1155/2012/397178 |
| spellingShingle | Shigeki Machida Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases Journal of Ophthalmology |
| title | Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases |
| title_full | Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases |
| title_fullStr | Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases |
| title_full_unstemmed | Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases |
| title_short | Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases |
| title_sort | clinical applications of the photopic negative response to optic nerve and retinal diseases |
| url | http://dx.doi.org/10.1155/2012/397178 |
| work_keys_str_mv | AT shigekimachida clinicalapplicationsofthephotopicnegativeresponsetoopticnerveandretinaldiseases |