On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule
Glucosamine is part of the human metabolome required for the biosynthesis of polymer glycosaminoglycans in connective tissue. In addition, the glucosamine molecule itself has anti-inflammatory and regenerative properties. This paper presents the results of a systematic analysis of fundamental and cl...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2019-09-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/946 |
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| author | I. Yu. Torshin A. M. Lila O. A. Gromova A. V. Naumov A. N. Gromov |
| author_facet | I. Yu. Torshin A. M. Lila O. A. Gromova A. V. Naumov A. N. Gromov |
| author_sort | I. Yu. Torshin |
| collection | DOAJ |
| description | Glucosamine is part of the human metabolome required for the biosynthesis of polymer glycosaminoglycans in connective tissue. In addition, the glucosamine molecule itself has anti-inflammatory and regenerative properties. This paper presents the results of a systematic analysis of fundamental and clinical studies, which indicate the anticoagulant and antiaggregatory effects of a highly purified pharmaceutical substance of microcrystalline glucosamine sulfate (mGS). The main molecular mechanisms of its antithrombotic effects are most probably the mGS molecular mimicry of heparan sulfate activity, the activation of CD44 receptor, and the inactivation of the NF-KB signaling pathways in platelets. A quantitative chemoreactome study has shown that the antithrombotic effects of mGS in the human reactome are due to the inhibition of: ’) proper platelet aggregation; 2) platelet adhesion and activation receptors; 3) endogenous synthesis of thromboxanes; 4) coagulation by reducing the activity of coagulation factors. |
| format | Article |
| id | doaj-art-a80b0fedeadb4560b79d55b00be4cb72 |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-a80b0fedeadb4560b79d55b00be4cb722025-08-20T03:59:56ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2019-09-0113313514110.14412/1996-7012-2019-3-135-1412202On the anticoagulant and antiaggregatory properties of a glucosamine sulfate moleculeI. Yu. Torshin0A. M. Lila1O. A. Gromova2A. V. Naumov3A. N. Gromov4Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management, Russian Academy of SciencesV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Management, Russian Academy of SciencesRussian Gerontology Research and Clinical Center, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Management, Russian Academy of SciencesGlucosamine is part of the human metabolome required for the biosynthesis of polymer glycosaminoglycans in connective tissue. In addition, the glucosamine molecule itself has anti-inflammatory and regenerative properties. This paper presents the results of a systematic analysis of fundamental and clinical studies, which indicate the anticoagulant and antiaggregatory effects of a highly purified pharmaceutical substance of microcrystalline glucosamine sulfate (mGS). The main molecular mechanisms of its antithrombotic effects are most probably the mGS molecular mimicry of heparan sulfate activity, the activation of CD44 receptor, and the inactivation of the NF-KB signaling pathways in platelets. A quantitative chemoreactome study has shown that the antithrombotic effects of mGS in the human reactome are due to the inhibition of: ’) proper platelet aggregation; 2) platelet adhesion and activation receptors; 3) endogenous synthesis of thromboxanes; 4) coagulation by reducing the activity of coagulation factors.https://mrj.ima-press.net/mrj/article/view/946microcrystalline glucosamine sulfatesustaquard artroantiaggregatory effectanticoagulant effect |
| spellingShingle | I. Yu. Torshin A. M. Lila O. A. Gromova A. V. Naumov A. N. Gromov On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule Современная ревматология microcrystalline glucosamine sulfate sustaquard artro antiaggregatory effect anticoagulant effect |
| title | On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| title_full | On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| title_fullStr | On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| title_full_unstemmed | On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| title_short | On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| title_sort | on the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule |
| topic | microcrystalline glucosamine sulfate sustaquard artro antiaggregatory effect anticoagulant effect |
| url | https://mrj.ima-press.net/mrj/article/view/946 |
| work_keys_str_mv | AT iyutorshin ontheanticoagulantandantiaggregatorypropertiesofaglucosaminesulfatemolecule AT amlila ontheanticoagulantandantiaggregatorypropertiesofaglucosaminesulfatemolecule AT oagromova ontheanticoagulantandantiaggregatorypropertiesofaglucosaminesulfatemolecule AT avnaumov ontheanticoagulantandantiaggregatorypropertiesofaglucosaminesulfatemolecule AT angromov ontheanticoagulantandantiaggregatorypropertiesofaglucosaminesulfatemolecule |