Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults
Abstract Background Systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) have recently emerged as more comprehensive indicators of systemic inflammation. However, few studies have been conducted to evaluate the effect of serum cotinine levels and weight-adjusted w...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-23272-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849725136983293952 |
|---|---|
| author | Yican Wang Wanting He Yong Zhou Xiaoqiang Qiu Qian Liao Peng Tang |
| author_facet | Yican Wang Wanting He Yong Zhou Xiaoqiang Qiu Qian Liao Peng Tang |
| author_sort | Yican Wang |
| collection | DOAJ |
| description | Abstract Background Systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) have recently emerged as more comprehensive indicators of systemic inflammation. However, few studies have been conducted to evaluate the effect of serum cotinine levels and weight-adjusted waist index (WWI) with SII and SIRI. This study aims to evaluate the independent and combined impact of serum cotinine levels and WWI with SII and SIRI. Methods This study enrolled 9,099 adults based on the National Health and Nutrition Examination Survey 2013–2016. Generalized linear models were employed to assess the associations between cotinine exposure and WWI with SII and SIRI. Moreover, smoothing curve fitting was conducted to investigate the potential nonlinear relationships between the WWI with SII and SIRI levels. Additionally, subgroup analyses and interaction tests were conducted. The combined associations of the WWI and cotinine with systemic inflammatory indices were further assessed. Results High serum cotinine exposure was associated with increased SII and SIRI. The WWI was positively correlated with SII and SIRI. Smoothing curve fitting demonstrated a nonlinearly increasing dose-response connection between WWI and SII and SIRI. Stratified analyses also showed a positive association of cotinine levels and WWI with the systemic inflammatory indices across subgroups. Furthermore, a positive joint association was observed between serum cotinine level and WWI with SII and SIRI. Conclusions These findings suggest that serum cotinine levels and WWI may be positively related to SII and SIRI. Serum cotinine levels and WWI may have a positive combined effect. |
| format | Article |
| id | doaj-art-a80736d5d93f41a6a94d545bb9d1f03e |
| institution | DOAJ |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-a80736d5d93f41a6a94d545bb9d1f03e2025-08-20T03:10:32ZengBMCBMC Public Health1471-24582025-06-012511910.1186/s12889-025-23272-4Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adultsYican Wang0Wanting He1Yong Zhou2Xiaoqiang Qiu3Qian Liao4Peng Tang5Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-sen UniversitySchool of Public Health, Xiangnan UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical UniversityAbstract Background Systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) have recently emerged as more comprehensive indicators of systemic inflammation. However, few studies have been conducted to evaluate the effect of serum cotinine levels and weight-adjusted waist index (WWI) with SII and SIRI. This study aims to evaluate the independent and combined impact of serum cotinine levels and WWI with SII and SIRI. Methods This study enrolled 9,099 adults based on the National Health and Nutrition Examination Survey 2013–2016. Generalized linear models were employed to assess the associations between cotinine exposure and WWI with SII and SIRI. Moreover, smoothing curve fitting was conducted to investigate the potential nonlinear relationships between the WWI with SII and SIRI levels. Additionally, subgroup analyses and interaction tests were conducted. The combined associations of the WWI and cotinine with systemic inflammatory indices were further assessed. Results High serum cotinine exposure was associated with increased SII and SIRI. The WWI was positively correlated with SII and SIRI. Smoothing curve fitting demonstrated a nonlinearly increasing dose-response connection between WWI and SII and SIRI. Stratified analyses also showed a positive association of cotinine levels and WWI with the systemic inflammatory indices across subgroups. Furthermore, a positive joint association was observed between serum cotinine level and WWI with SII and SIRI. Conclusions These findings suggest that serum cotinine levels and WWI may be positively related to SII and SIRI. Serum cotinine levels and WWI may have a positive combined effect.https://doi.org/10.1186/s12889-025-23272-4CotinineNHANESSystemic immune inflammation indexSystem inflammation response indexWeight-adjusted waist index |
| spellingShingle | Yican Wang Wanting He Yong Zhou Xiaoqiang Qiu Qian Liao Peng Tang Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults BMC Public Health Cotinine NHANES Systemic immune inflammation index System inflammation response index Weight-adjusted waist index |
| title | Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| title_full | Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| title_fullStr | Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| title_full_unstemmed | Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| title_short | Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| title_sort | joint association of weight adjusted waist index and serum cotinine levels with systemic inflammatory index in adults |
| topic | Cotinine NHANES Systemic immune inflammation index System inflammation response index Weight-adjusted waist index |
| url | https://doi.org/10.1186/s12889-025-23272-4 |
| work_keys_str_mv | AT yicanwang jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults AT wantinghe jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults AT yongzhou jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults AT xiaoqiangqiu jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults AT qianliao jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults AT pengtang jointassociationofweightadjustedwaistindexandserumcotininelevelswithsystemicinflammatoryindexinadults |