Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer
In recent years，the comorbidity of CRC and DM has become more and more common，and has become one of the public health problems that seriously endanger human health. The pathological mechanisms of DM such as hyperglycemia，insulin resistance and chronic inflammation can promote the progression of CRC....
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| Format: | Article |
| Language: | zho |
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The Editorial Department of Chinese Journal of Clinical Research
2025-07-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250702 |
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| author | ZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li |
| author_facet | ZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li |
| author_sort | ZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li |
| collection | DOAJ |
| description | In recent years，the comorbidity of CRC and DM has become more and more common，and has become one of the public health problems that seriously endanger human health. The pathological mechanisms of DM such as hyperglycemia，insulin resistance and chronic inflammation can promote the progression of CRC.In addition，the effects of hypoglycemic drugs such as insulin，metformin，glucagon-like peptide-1 receptor agonist and SGLT2ion the prognosis of patients with T2DM complicated with CRC are also controversial. This article will comprehensively analyze the molecular mechanism of T2DM affecting the prognosis of CRC and the effects of different hypoglycemic drugs on the prognosis of CRC patients with T2DM.
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| format | Article |
| id | doaj-art-a806990b7e354d2ca0485cb3d4a0a8fa |
| institution | Kabale University |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-a806990b7e354d2ca0485cb3d4a0a8fa2025-08-25T06:50:34ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822025-07-0138798398710.13429/j.cnki.cjcr.2025.07.002Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancerZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li0Department of Oncology，the Second Affiliated Hospital of Kunming Medical University，Kunming，Yunnan 650000，ChinaIn recent years，the comorbidity of CRC and DM has become more and more common，and has become one of the public health problems that seriously endanger human health. The pathological mechanisms of DM such as hyperglycemia，insulin resistance and chronic inflammation can promote the progression of CRC.In addition，the effects of hypoglycemic drugs such as insulin，metformin，glucagon-like peptide-1 receptor agonist and SGLT2ion the prognosis of patients with T2DM complicated with CRC are also controversial. This article will comprehensively analyze the molecular mechanism of T2DM affecting the prognosis of CRC and the effects of different hypoglycemic drugs on the prognosis of CRC patients with T2DM. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250702colorectal cancertype 2 diabetesinsulin resistanceglucagon-like peptide-1 receptor agonistsglt2 inhibitorprognosis |
| spellingShingle | ZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer Zhongguo linchuang yanjiu colorectal cancer type 2 diabetes insulin resistance glucagon-like peptide-1 receptor agonist sglt2 inhibitor prognosis |
| title | Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| title_full | Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| title_fullStr | Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| title_full_unstemmed | Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| title_short | Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| title_sort | research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer |
| topic | colorectal cancer type 2 diabetes insulin resistance glucagon-like peptide-1 receptor agonist sglt2 inhibitor prognosis |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250702 |
| work_keys_str_mv | AT zhangmengleixuefenchenhaixiachenyixuanjiangli researchprogressontheeffectoftype2diabetesandhypoglycemicdrugsontheprognosisofpatientswithcolorectalcancer |