Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling

Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling

Background. Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. This study demonstrates the antiangiogenic effects of scutellarin (SCU) on high glucose- and hypoxia-stimulated human retinal endothelial cells (HRECs) and on a diabetic rat model by oral administration. The a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lingli Long, Yubin Li, Shuang Yu, Xiang Li, Yue Hu, Tengfei Long, Liqin Wang, Wenwen Li, Xiaoxin Ye, Zunfu Ke, Haipeng Xiao
Format:	Article
Language:	English
Published:	Wiley 2019-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2019/4875421
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy
by: Yuexiu Wu, et al.
Published: (2010-01-01)

Hydrolyzed Collagen from Salmon Skin Increases the Migration and Filopodia Formation of Skin Keratinocytes by Activation of FAK/Src Pathway
by: Wanwipha Woonnoi, et al.
Published: (2021-09-01)

Anti-VEGF Agents for Ocular Angiogenesis and Vascular Permeability
by: Kenichi Kimoto, et al.
Published: (2012-01-01)

Sargassum plagiophyllum Ethanolic Extract Enhances Wound Healing by Modulating FAK/Src/Akt/p38 and Rac1 Signaling in Keratinocytes HaCaT Cells
by: Furoida Moolsup, et al.
Published: (2025-01-01)

VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy
by: Caroline Hilmi, et al.
Published: (2012-01-01)

Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B
by: Xingyong Chen, et al.
Published: (2013-01-01)

Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization
by: Danyue Li, et al.
Published: (2025-02-01)

Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
by: Selwyn M. Prea, et al.
Published: (2015-01-01)

Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling
by: Ying Cheng, et al.
Published: (2025-02-01)

Anti-VEGF in a Marathon Runner’s Retinopathy Case
by: Alexander Kahjun Soon, et al.
Published: (2016-01-01)

Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma
by: Seema Chugh, et al.
Published: (2025-02-01)

DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway
by: Liang Sun, et al.
Published: (2018-01-01)

Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway
by: Yue He, et al.
Published: (2025-02-01)

Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment
by: Denghao Huang, et al.
Published: (2022-01-01)

Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling.
by: Xiu-Ying He, et al.
Published: (2025-01-01)

Strength prediction and failure mode classification for SRC shear beams using GA-BP ANN method
by: Gangfeng Yao, et al.
Published: (2025-07-01)

Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6
by: Dubravko Jelić, et al.
Published: (2016-01-01)

Puerarin Promotes the Migration and Differentiation of Myoblasts by Activating the FAK and PI3K/AKT Signaling Pathways
by: Xiaofeng Fang, et al.
Published: (2025-01-01)

hCTLA4-Gene-Modified Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMMSCs) Maintain POSTN Secretion to Enhance the Migration Capability of Allogeneic hBMMSCs through the Integrin αvβ3/FAK/ERK Signaling Pathway
by: Lei Song, et al.
Published: (2020-01-01)

Combined Tractional and Rhegmatogenous Retinal Detachment in Proliferative Diabetic Retinopathy in the Anti-VEGF Era
by: Ya-Jui Hsu, et al.
Published: (2014-01-01)

A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy
by: Robert Hodgson, et al.
Published: (2025-01-01)

Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway
by: Jianjian Wang, et al.
Published: (2025-01-01)

Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors
by: Yuhui Yang, et al.
Published: (2025-02-01)

Experimental and numerical study on seismic behaviors of SRC column-RC slab joints in NPP
by: Dayang Wang, et al.
Published: (2025-02-01)

DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice
by: Lixia Tian, et al.
Published: (2025-02-01)

Rat Hippocampal Neural Stem Cell Modulation Using PDGF, VEGF, PDGF/VEGF, and BDNF
by: Neus Gomila Pelegri, et al.
Published: (2019-01-01)

Puerarin Suppress Apoptosis of Human Osteoblasts via ERK Signaling Pathway
by: Ling-juan Liu, et al.
Published: (2013-01-01)

Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer
by: Jinbao Chen, et al.
Published: (2025-02-01)

VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2
by: Chengshi Xu, et al.
Published: (2013-01-01)

Established Digital Model of Fruit Body Growth of Agrocybe cylindracea Based on Network Programming
by: Long Wang, et al.
Published: (2021-01-01)

Complex System Analysis of Blumeria graminis f.sp. tritici Isolates Collected in Central Hebei Province, China
by: Qingping Zhou, et al.
Published: (2021-01-01)

Polymorphism of angiogenesis regulation factor genes (<i>VEGF/VEGFR</i>), and extracellular matrix remodeling genes (<i>MMP/TIMP</i>), and the levels of their products in extracellular tissues of patients with primary and secondary lymphedema
by: V. I. Konenkov, et al.
Published: (2024-07-01)

Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt.
by: Alyssa Hubal, et al.
Published: (2025-01-01)

ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action
by: Jeong-Oog Lee, et al.
Published: (2015-01-01)

The Interaction of Src Kinase with β3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer
by: Stephan Huveneers, et al.
Published: (2010-01-01)

Damage Assessment of an SRC Frame-Core Tube Structure under the Action of a Main Aftershock Sequence
by: Peng Wang, et al.
Published: (2020-01-01)

Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways
by: Li Gong, et al.
Published: (2024-12-01)

Cell-Oriented Modeling of Angiogenesis
by: Diego Guidolin, et al.
Published: (2011-01-01)

Angiogenesis and Its Therapeutic Opportunities
by: So Young Yoo, et al.
Published: (2013-01-01)

Endometriosis, Angiogenesis and Tissue Factor
by: Graciela Krikun
Published: (2012-01-01)