Neurolymphomatosis of T‐Cell Origin in a Dog
ABSTRACT A 10‐year‐old mixed‐breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T‐cell lymphoma. Chemotherapy...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70189 |
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| author | Marie‐Kerstin Müller Michaela Irmscher Nadja Goldbach Alexander F. H. Haake Olivia Kershaw Penelope A. Baloi |
| author_facet | Marie‐Kerstin Müller Michaela Irmscher Nadja Goldbach Alexander F. H. Haake Olivia Kershaw Penelope A. Baloi |
| author_sort | Marie‐Kerstin Müller |
| collection | DOAJ |
| description | ABSTRACT A 10‐year‐old mixed‐breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T‐cell lymphoma. Chemotherapy ensued with no improvement of clinical signs. Cerebrospinal fluid reanalysis still revealed a mild lymphocytic pleocytosis. MRI of the brain and spinal cord solely showed a reduced ventral subarachnoid and epidural space (Th11‐L2) and mild enlargement of the central canal in this area. Postmortem examination revealed thickening of the spinal nerve roots and ganglia. Histologically, a marked intraspinal‐subdural and intraneural, as well as intra‐ganglionic, infiltration by large lymphocytes in the peripheral nervous system was visible. Immunohistochemically, the infiltrating lymphoblasts were CD3 positive, confirming T‐cell origin. Neurolymphomatosis is a rarely described neoplastic disease in dogs. The present case highlights the importance of analysis of CSF in neurologically abnormal dogs. |
| format | Article |
| id | doaj-art-a804a1dfb08a42f28f6462932a124f73 |
| institution | DOAJ |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-a804a1dfb08a42f28f6462932a124f732025-08-20T03:09:35ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-07-01394n/an/a10.1111/jvim.70189Neurolymphomatosis of T‐Cell Origin in a DogMarie‐Kerstin Müller0Michaela Irmscher1Nadja Goldbach2Alexander F. H. Haake3Olivia Kershaw4Penelope A. Baloi5AniCura Potsdam GmbH Potsdam GermanyAniCura Potsdam GmbH Potsdam GermanyTierarztpraxis Dr. Soerensen GmbH Berlin GermanyInstitut für Tierpathologie, Freie Universität Berlin Berlin GermanyInstitut für Tierpathologie, Freie Universität Berlin Berlin GermanyVet‐CT Cambridge UKABSTRACT A 10‐year‐old mixed‐breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T‐cell lymphoma. Chemotherapy ensued with no improvement of clinical signs. Cerebrospinal fluid reanalysis still revealed a mild lymphocytic pleocytosis. MRI of the brain and spinal cord solely showed a reduced ventral subarachnoid and epidural space (Th11‐L2) and mild enlargement of the central canal in this area. Postmortem examination revealed thickening of the spinal nerve roots and ganglia. Histologically, a marked intraspinal‐subdural and intraneural, as well as intra‐ganglionic, infiltration by large lymphocytes in the peripheral nervous system was visible. Immunohistochemically, the infiltrating lymphoblasts were CD3 positive, confirming T‐cell origin. Neurolymphomatosis is a rarely described neoplastic disease in dogs. The present case highlights the importance of analysis of CSF in neurologically abnormal dogs.https://doi.org/10.1111/jvim.70189caninehistopathologyperipheral nervous systemT‐cell lymphoma |
| spellingShingle | Marie‐Kerstin Müller Michaela Irmscher Nadja Goldbach Alexander F. H. Haake Olivia Kershaw Penelope A. Baloi Neurolymphomatosis of T‐Cell Origin in a Dog Journal of Veterinary Internal Medicine canine histopathology peripheral nervous system T‐cell lymphoma |
| title | Neurolymphomatosis of T‐Cell Origin in a Dog |
| title_full | Neurolymphomatosis of T‐Cell Origin in a Dog |
| title_fullStr | Neurolymphomatosis of T‐Cell Origin in a Dog |
| title_full_unstemmed | Neurolymphomatosis of T‐Cell Origin in a Dog |
| title_short | Neurolymphomatosis of T‐Cell Origin in a Dog |
| title_sort | neurolymphomatosis of t cell origin in a dog |
| topic | canine histopathology peripheral nervous system T‐cell lymphoma |
| url | https://doi.org/10.1111/jvim.70189 |
| work_keys_str_mv | AT mariekerstinmuller neurolymphomatosisoftcellorigininadog AT michaelairmscher neurolymphomatosisoftcellorigininadog AT nadjagoldbach neurolymphomatosisoftcellorigininadog AT alexanderfhhaake neurolymphomatosisoftcellorigininadog AT oliviakershaw neurolymphomatosisoftcellorigininadog AT penelopeabaloi neurolymphomatosisoftcellorigininadog |