Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network
Background: Fertility preservation (FP) is a key aspect of care for young women with breast cancer (BC), as oncologic treatments can compromise future reproductive potential. Early counseling and access to FP strategies are essential to support long-term quality of life. Objectives: To evaluate the...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-07-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359251341210 |
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| author | Gabriella Gentile Cristiano Tesei Stefania Brunetti Paola Cavaceppi Giuseppe Sorrenti Matteo Lambertini Mariavita Ciccarone |
| author_facet | Gabriella Gentile Cristiano Tesei Stefania Brunetti Paola Cavaceppi Giuseppe Sorrenti Matteo Lambertini Mariavita Ciccarone |
| author_sort | Gabriella Gentile |
| collection | DOAJ |
| description | Background: Fertility preservation (FP) is a key aspect of care for young women with breast cancer (BC), as oncologic treatments can compromise future reproductive potential. Early counseling and access to FP strategies are essential to support long-term quality of life. Objectives: To evaluate the uptake of FP counseling, the choice of preservation techniques, and reproductive outcomes in women aged 18–39 years with BC. Design: A retrospective single-center cohort study was conducted at the Gemme Dormienti network between 2018 and 2023. Methods: A total of 100 BC patients underwent baseline ovarian reserve assessments, including hormonal and ultrasound evaluations. All received gonadotropin-releasing hormone agonist therapy prior to chemotherapy. Data on FP strategies—oocyte and/or ovarian tissue cryopreservation (OTC)—and pregnancy outcomes were collected. Results: Fifty-four percent of patients pursued FP procedures: 35% underwent oocyte cryopreservation, 55% OTC, and 10% both. Younger patients (18–29 years) were more likely to opt for combined techniques. Pregnancy rates were highest among women aged 35–39. Ovarian reserve indicators, including antral follicle count and endometrial thickness, showed an age-related decline. Conclusion: This study highlights the importance of early, personalized FP counseling for young BC patients. Age significantly influences both FP choices and reproductive outcomes, reinforcing the need to integrate fertility discussions into initial cancer care. |
| format | Article |
| id | doaj-art-a8040a012d544f83a47280be22bfc061 |
| institution | Kabale University |
| issn | 1758-8359 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-a8040a012d544f83a47280be22bfc0612025-08-20T03:50:40ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592025-07-011710.1177/17588359251341210Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti networkGabriella GentileCristiano TeseiStefania BrunettiPaola CavaceppiGiuseppe SorrentiMatteo LambertiniMariavita CiccaroneBackground: Fertility preservation (FP) is a key aspect of care for young women with breast cancer (BC), as oncologic treatments can compromise future reproductive potential. Early counseling and access to FP strategies are essential to support long-term quality of life. Objectives: To evaluate the uptake of FP counseling, the choice of preservation techniques, and reproductive outcomes in women aged 18–39 years with BC. Design: A retrospective single-center cohort study was conducted at the Gemme Dormienti network between 2018 and 2023. Methods: A total of 100 BC patients underwent baseline ovarian reserve assessments, including hormonal and ultrasound evaluations. All received gonadotropin-releasing hormone agonist therapy prior to chemotherapy. Data on FP strategies—oocyte and/or ovarian tissue cryopreservation (OTC)—and pregnancy outcomes were collected. Results: Fifty-four percent of patients pursued FP procedures: 35% underwent oocyte cryopreservation, 55% OTC, and 10% both. Younger patients (18–29 years) were more likely to opt for combined techniques. Pregnancy rates were highest among women aged 35–39. Ovarian reserve indicators, including antral follicle count and endometrial thickness, showed an age-related decline. Conclusion: This study highlights the importance of early, personalized FP counseling for young BC patients. Age significantly influences both FP choices and reproductive outcomes, reinforcing the need to integrate fertility discussions into initial cancer care.https://doi.org/10.1177/17588359251341210 |
| spellingShingle | Gabriella Gentile Cristiano Tesei Stefania Brunetti Paola Cavaceppi Giuseppe Sorrenti Matteo Lambertini Mariavita Ciccarone Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network Therapeutic Advances in Medical Oncology |
| title | Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network |
| title_full | Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network |
| title_fullStr | Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network |
| title_full_unstemmed | Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network |
| title_short | Fertility preservation in young patients with breast cancer: insights from the Gemme Dormienti network |
| title_sort | fertility preservation in young patients with breast cancer insights from the gemme dormienti network |
| url | https://doi.org/10.1177/17588359251341210 |
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