Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring
Maternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and still...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/741613 |
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| author | Vicki L. Clifton Michael Davies Vivienne Moore Ian M. R. Wright Zainab Ali Nicolette A. Hodyl |
| author_facet | Vicki L. Clifton Michael Davies Vivienne Moore Ian M. R. Wright Zainab Ali Nicolette A. Hodyl |
| author_sort | Vicki L. Clifton |
| collection | DOAJ |
| description | Maternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and stillbirth. Asthma therefore represents a significant health burden to society and could have an impact on the lifelong health of the children of women with asthma. Our research has identified that maternal asthma in pregnancy induces placental dysfunction and developmental perturbation in the fetus in a sex specific manner. These alterations in development could increase the risk of metabolic disease in adulthood of children of asthmatic mothers, especially females. In this paper, we will discuss the evidence currently available that supports the hypothesis that children of mothers with asthma may be at risk of lifelong health complications which include diabetes and hypertension. |
| format | Article |
| id | doaj-art-a8031415e8874f8cac3fc015e45e8272 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-a8031415e8874f8cac3fc015e45e82722025-02-03T01:31:32ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/741613741613Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on OffspringVicki L. Clifton0Michael Davies1Vivienne Moore2Ian M. R. Wright3Zainab Ali4Nicolette A. Hodyl5Robinson Institute, University of Adelaide, Adelaide, SA 5005, AustraliaRobinson Institute, University of Adelaide, Adelaide, SA 5005, AustraliaRobinson Institute, University of Adelaide, Adelaide, SA 5005, AustraliaMothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, NSW 2310, AustraliaRobinson Institute, University of Adelaide, Adelaide, SA 5005, AustraliaRobinson Institute, University of Adelaide, Adelaide, SA 5005, AustraliaMaternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and stillbirth. Asthma therefore represents a significant health burden to society and could have an impact on the lifelong health of the children of women with asthma. Our research has identified that maternal asthma in pregnancy induces placental dysfunction and developmental perturbation in the fetus in a sex specific manner. These alterations in development could increase the risk of metabolic disease in adulthood of children of asthmatic mothers, especially females. In this paper, we will discuss the evidence currently available that supports the hypothesis that children of mothers with asthma may be at risk of lifelong health complications which include diabetes and hypertension.http://dx.doi.org/10.1155/2012/741613 |
| spellingShingle | Vicki L. Clifton Michael Davies Vivienne Moore Ian M. R. Wright Zainab Ali Nicolette A. Hodyl Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring Journal of Pregnancy |
| title | Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring |
| title_full | Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring |
| title_fullStr | Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring |
| title_full_unstemmed | Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring |
| title_short | Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring |
| title_sort | developmental perturbation induced by maternal asthma during pregnancy the short and long term impacts on offspring |
| url | http://dx.doi.org/10.1155/2012/741613 |
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