Dexmedetomidine reduces acute lung injury caused by LPS through the SIRT3 signaling pathway in vivo

Dexmedetomidine reduces acute lung injury caused by LPS through the SIRT3 signaling pathway in vivo

Acute lung injury (ALI) is a clinical syndrome characterized by excessive inflammatory responses. Despite the exploration of various therapeutic approaches, no effective pharmacological treatment is currently available for ALI. In the current study, we investigated the role of SIRT3 in LPS-induced A...

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Bibliographic Details
Main Authors: Jian Chen, Yang Cai, Xiaochun Peng, Yuanling Xu, Liying Chen, Xinxin Pan, Yingying Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
sirt3
dexmedetomidine
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1524219/full
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