The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
Abstract Background Chronic diseases such as obesity, hypertension, and metabolic syndrome are major health concerns worldwide. Ursodeoxycholic acid (UDCA) is a bile acid that is naturally produced in the liver and has been used for the treatment of various liver disorders. In this systematic review...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-025-04549-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849724093633396736 |
|---|---|
| author | Elaheh Rashidbeygi Niloufar Rasaei Mohammad Reza Amini Marieh Salavatizadeh Mehdi Mohammadizadeh Azita Hekmatdoost |
| author_facet | Elaheh Rashidbeygi Niloufar Rasaei Mohammad Reza Amini Marieh Salavatizadeh Mehdi Mohammadizadeh Azita Hekmatdoost |
| author_sort | Elaheh Rashidbeygi |
| collection | DOAJ |
| description | Abstract Background Chronic diseases such as obesity, hypertension, and metabolic syndrome are major health concerns worldwide. Ursodeoxycholic acid (UDCA) is a bile acid that is naturally produced in the liver and has been used for the treatment of various liver disorders. In this systematic review and meta-analysis, we investigated how UDCA might affect inflammation, blood pressure, and obesity. Methods Five major databases were searched from inception to August 2024. The investigated outcomes included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). A random effect was carried out to estimate pooled weighted mean difference (WMD) with 95% confidence intervals (CI). The registration code is CRD42023428064. Results Of the 7912 articles in the initial search, 12 were included in the systematic review and meta-analysis. UDCA consumption significantly decreased BMI (WMD: -0.29 kg/m2, 95% CI: -0.58, -0.01, P = 0.044), and DBP (WMD: -2.16 mmHg, 95% CI: -3.66, -0.66, P = 0.005). It also increased SBP (WMD: 5.50 mmHg, 95% CI: 3.65, 7.35, P < 0.001); however, it was not associated with weight loss (WMD: -0.3 kg, 95% CI: -1.3, 0.71, P = 0.561). Our systematic review showed that UDCA consumption has no effect on IL-6 and TNF-α. Conclusion This systematic review and meta-analysis suggest that UDCA supplementation may improve BMI and DBP, whereas it may increase SBP and have no effect on weight or inflammation. Further long-term and well-designed RCTs are needed to further assess and confirm these results. |
| format | Article |
| id | doaj-art-a7fdcaeeeaf849ac8dc7731895fea8ed |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-a7fdcaeeeaf849ac8dc7731895fea8ed2025-08-20T03:10:50ZengBMCBMC Cardiovascular Disorders1471-22612025-02-0125111410.1186/s12872-025-04549-3The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trialsElaheh Rashidbeygi0Niloufar Rasaei1Mohammad Reza Amini2Marieh Salavatizadeh3Mehdi Mohammadizadeh4Azita Hekmatdoost5Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesMicronutrient Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesNutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesStudent Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesAbstract Background Chronic diseases such as obesity, hypertension, and metabolic syndrome are major health concerns worldwide. Ursodeoxycholic acid (UDCA) is a bile acid that is naturally produced in the liver and has been used for the treatment of various liver disorders. In this systematic review and meta-analysis, we investigated how UDCA might affect inflammation, blood pressure, and obesity. Methods Five major databases were searched from inception to August 2024. The investigated outcomes included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). A random effect was carried out to estimate pooled weighted mean difference (WMD) with 95% confidence intervals (CI). The registration code is CRD42023428064. Results Of the 7912 articles in the initial search, 12 were included in the systematic review and meta-analysis. UDCA consumption significantly decreased BMI (WMD: -0.29 kg/m2, 95% CI: -0.58, -0.01, P = 0.044), and DBP (WMD: -2.16 mmHg, 95% CI: -3.66, -0.66, P = 0.005). It also increased SBP (WMD: 5.50 mmHg, 95% CI: 3.65, 7.35, P < 0.001); however, it was not associated with weight loss (WMD: -0.3 kg, 95% CI: -1.3, 0.71, P = 0.561). Our systematic review showed that UDCA consumption has no effect on IL-6 and TNF-α. Conclusion This systematic review and meta-analysis suggest that UDCA supplementation may improve BMI and DBP, whereas it may increase SBP and have no effect on weight or inflammation. Further long-term and well-designed RCTs are needed to further assess and confirm these results.https://doi.org/10.1186/s12872-025-04549-3Ursodeoxycholic acidBlood pressureBody weightMeta-analysisInflammation |
| spellingShingle | Elaheh Rashidbeygi Niloufar Rasaei Mohammad Reza Amini Marieh Salavatizadeh Mehdi Mohammadizadeh Azita Hekmatdoost The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials BMC Cardiovascular Disorders Ursodeoxycholic acid Blood pressure Body weight Meta-analysis Inflammation |
| title | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| title_full | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| title_short | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | effects of ursodeoxycholic acid on cardiometabolic risk factors a systematic review and meta analysis of randomized controlled trials |
| topic | Ursodeoxycholic acid Blood pressure Body weight Meta-analysis Inflammation |
| url | https://doi.org/10.1186/s12872-025-04549-3 |
| work_keys_str_mv | AT elahehrashidbeygi theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT niloufarrasaei theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mohammadrezaamini theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mariehsalavatizadeh theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mehdimohammadizadeh theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT azitahekmatdoost theeffectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT elahehrashidbeygi effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT niloufarrasaei effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mohammadrezaamini effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mariehsalavatizadeh effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT mehdimohammadizadeh effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT azitahekmatdoost effectsofursodeoxycholicacidoncardiometabolicriskfactorsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |