Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats
The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/839095 |
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| author | Miguel Roehrs Cassieli Gehlen Figueiredo Mariane Magalhães Zanchi Guilherme Vargas Bochi Rafael Noal Moresco Andréia Quatrin Sabrina Somacal Lisiane Conte Tatiana Emanuelli |
| author_facet | Miguel Roehrs Cassieli Gehlen Figueiredo Mariane Magalhães Zanchi Guilherme Vargas Bochi Rafael Noal Moresco Andréia Quatrin Sabrina Somacal Lisiane Conte Tatiana Emanuelli |
| author_sort | Miguel Roehrs |
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| description | The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes. |
| format | Article |
| id | doaj-art-a7f5692234fa4dbbb21b15b5b8d936b8 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a7f5692234fa4dbbb21b15b5b8d936b82025-08-20T02:20:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/839095839095Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic RatsMiguel Roehrs0Cassieli Gehlen Figueiredo1Mariane Magalhães Zanchi2Guilherme Vargas Bochi3Rafael Noal Moresco4Andréia Quatrin5Sabrina Somacal6Lisiane Conte7Tatiana Emanuelli8Graduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilIntegrated Center for Laboratory Analysis Development (NIDAL), Department of Alimentary Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilIntegrated Center for Laboratory Analysis Development (NIDAL), Department of Alimentary Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilIntegrated Center for Laboratory Analysis Development (NIDAL), Department of Alimentary Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, BrazilThe present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.http://dx.doi.org/10.1155/2014/839095 |
| spellingShingle | Miguel Roehrs Cassieli Gehlen Figueiredo Mariane Magalhães Zanchi Guilherme Vargas Bochi Rafael Noal Moresco Andréia Quatrin Sabrina Somacal Lisiane Conte Tatiana Emanuelli Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats International Journal of Endocrinology |
| title | Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_full | Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_short | Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_sort | bixin and norbixin have opposite effects on glycemia lipidemia and oxidative stress in streptozotocin induced diabetic rats |
| url | http://dx.doi.org/10.1155/2014/839095 |
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