IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential

IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential

Interleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form the IL-33/Suppression of tumorigenicity 2 (ST2)...

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Bibliographic Details
Main Authors: Feiya Sheng, Mi Li, Jia-Mei Yu, Si-Yu Yang, Liang Zou, Guan-Jun Yang, Le-Le Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
interleukin-33
suppression of tumorigenicity 2
central nervous system
cancer
fibrosis
autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1533335/full
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