Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants
Objective: Bronchopulmonary dysplasia (BPD) is among the most common complications of prematurity and is associated with high morbidity and mortality rates. Acute kidney injury (AKI) is also commonly observed in premature infants and significantly increases morbidity and mortality. Studies have show...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-09-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-20599 |
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| _version_ | 1832582769820041216 |
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| author | Saime Hacer OZDEMIR Husnu Fahri OVALI |
| author_facet | Saime Hacer OZDEMIR Husnu Fahri OVALI |
| author_sort | Saime Hacer OZDEMIR |
| collection | DOAJ |
| description | Objective: Bronchopulmonary dysplasia (BPD) is among the most common complications of prematurity and is associated with high morbidity and mortality rates. Acute kidney injury (AKI) is also commonly observed in premature infants and significantly increases morbidity and mortality. Studies have shown that systemic changes in AKI may also trigger lung damage.
Methods: This study aimed to determine the effects of AKI on the development of BPD in preterm infants with a postconceptional age of ≤32 weeks and/or birth weight of ≤1500 grams. The relationship between demographic features and accompanying perinatal and postnatal morbidities among the patients was investigated.
Results: The incidence of BPD in infants with AKI was 52.6% (10 of 19 infants) and 38.3% (61 of 140 infants) in infants without AKI. In infants who developed BPD, the rate of AKI did not vary notably between babies born at ≤28 weeks and those born at >28 weeks [n=9, 17.3% (9 of 52 infants) and n= 1, 5.3%, (1 of 19 infants) respectively] of gestation (p>0.05).
Conclusions: AKI was associated with a greater need for resuscitation at birth, a greater need for invasive mechanical ventilation, fewer ventilatorfree days, and a higher incidence of sepsis, patent ductus arteriosus, and necrotizing enterocolitis in premature infants. It was also more frequently associated with fluid-electrolyte imbalance, blood pressure, and hemodynamic disorders in the first postnatal week. The rate of BPD development was higher in infants with AKI, but this disparity was not statistically notable (p>0.05). |
| format | Article |
| id | doaj-art-a7ec5cac041340c4a2a47275894dce21 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-a7ec5cac041340c4a2a47275894dce212025-01-29T10:22:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-09-0139315216010.4274/MMJ.galenos.2024.20599MEDJ-20599Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm InfantsSaime Hacer OZDEMIR0Husnu Fahri OVALI1Medeniyet University Faculty of Medicine, Department of Pediatrics, Istanbul, TürkiyeMedeniyet University Faculty of Medicine, Department of Pediatrics, Istanbul, TürkiyeObjective: Bronchopulmonary dysplasia (BPD) is among the most common complications of prematurity and is associated with high morbidity and mortality rates. Acute kidney injury (AKI) is also commonly observed in premature infants and significantly increases morbidity and mortality. Studies have shown that systemic changes in AKI may also trigger lung damage. Methods: This study aimed to determine the effects of AKI on the development of BPD in preterm infants with a postconceptional age of ≤32 weeks and/or birth weight of ≤1500 grams. The relationship between demographic features and accompanying perinatal and postnatal morbidities among the patients was investigated. Results: The incidence of BPD in infants with AKI was 52.6% (10 of 19 infants) and 38.3% (61 of 140 infants) in infants without AKI. In infants who developed BPD, the rate of AKI did not vary notably between babies born at ≤28 weeks and those born at >28 weeks [n=9, 17.3% (9 of 52 infants) and n= 1, 5.3%, (1 of 19 infants) respectively] of gestation (p>0.05). Conclusions: AKI was associated with a greater need for resuscitation at birth, a greater need for invasive mechanical ventilation, fewer ventilatorfree days, and a higher incidence of sepsis, patent ductus arteriosus, and necrotizing enterocolitis in premature infants. It was also more frequently associated with fluid-electrolyte imbalance, blood pressure, and hemodynamic disorders in the first postnatal week. The rate of BPD development was higher in infants with AKI, but this disparity was not statistically notable (p>0.05).https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-20599prematurityacute kidney injurybronchopulmonary dysplasiaorgan crosstalk |
| spellingShingle | Saime Hacer OZDEMIR Husnu Fahri OVALI Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants Medeniyet Medical Journal prematurity acute kidney injury bronchopulmonary dysplasia organ crosstalk |
| title | Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants |
| title_full | Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants |
| title_fullStr | Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants |
| title_full_unstemmed | Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants |
| title_short | Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants |
| title_sort | association of acute kidney injury with bronchopulmonary dysplasia in preterm infants |
| topic | prematurity acute kidney injury bronchopulmonary dysplasia organ crosstalk |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-20599 |
| work_keys_str_mv | AT saimehacerozdemir associationofacutekidneyinjurywithbronchopulmonarydysplasiainpreterminfants AT husnufahriovali associationofacutekidneyinjurywithbronchopulmonarydysplasiainpreterminfants |