Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?

Although SARS-COV-2 started in 2019, its losses are still significant, and it takes victims. In the present study, the epidemic patterns of SARS-COV-2 disease have been investigated from the point of view of mathematical modeling. Also, the effect of quarantine has been considered. This mathematical...

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Main Authors: Mohadeseh Najafi, Hamidreza Mortazavy Beni, Ashkan Heydarian, Samaneh Sadat Sajjadi, Ahmad Hajipour
Format: Article
Language:English
Published: SAGE Publishing 2025-04-01
Series:Biomedical Engineering and Computational Biology
Online Access:https://doi.org/10.1177/11795972251321306
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author Mohadeseh Najafi
Hamidreza Mortazavy Beni
Ashkan Heydarian
Samaneh Sadat Sajjadi
Ahmad Hajipour
author_facet Mohadeseh Najafi
Hamidreza Mortazavy Beni
Ashkan Heydarian
Samaneh Sadat Sajjadi
Ahmad Hajipour
author_sort Mohadeseh Najafi
collection DOAJ
description Although SARS-COV-2 started in 2019, its losses are still significant, and it takes victims. In the present study, the epidemic patterns of SARS-COV-2 disease have been investigated from the point of view of mathematical modeling. Also, the effect of quarantine has been considered. This mathematical model is designed in the form of fractional calculations along with a model predictive control (MPC) to monitor this model. The fractional-order model has the memory and hereditary properties of the system, which can provide more adjustable parameters to the designer. Because the MPC can predict future outputs, it can overcome the conditions and events that occur in the future. The results of the simulations show that the proposed nonlinear model predictive controller (NMPC) of fractional-order has a lower mean squared error in susceptible people compared to the optimal control of fractional-order (~3.6e-04 vs. 47.4). This proposed NMPC of fractional-order can be used for other models of epidemics.
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institution DOAJ
issn 1179-5972
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publishDate 2025-04-01
publisher SAGE Publishing
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series Biomedical Engineering and Computational Biology
spelling doaj-art-a7e811643feb46ccb72652e892980ae62025-08-20T03:18:13ZengSAGE PublishingBiomedical Engineering and Computational Biology1179-59722025-04-011610.1177/11795972251321306Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?Mohadeseh Najafi0Hamidreza Mortazavy Beni1Ashkan Heydarian2Samaneh Sadat Sajjadi3Ahmad Hajipour4Department of Electrical and Computer Engineering, Hakim Sabzevari University, Sabzevar, IranDepartment of Biomedical Engineering, Arsanjan Branch, Islamic Azad University, Arsanjan, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Electrical and Computer Engineering, Hakim Sabzevari University, Sabzevar, IranDepartment of Electrical and Computer Engineering, Hakim Sabzevari University, Sabzevar, IranAlthough SARS-COV-2 started in 2019, its losses are still significant, and it takes victims. In the present study, the epidemic patterns of SARS-COV-2 disease have been investigated from the point of view of mathematical modeling. Also, the effect of quarantine has been considered. This mathematical model is designed in the form of fractional calculations along with a model predictive control (MPC) to monitor this model. The fractional-order model has the memory and hereditary properties of the system, which can provide more adjustable parameters to the designer. Because the MPC can predict future outputs, it can overcome the conditions and events that occur in the future. The results of the simulations show that the proposed nonlinear model predictive controller (NMPC) of fractional-order has a lower mean squared error in susceptible people compared to the optimal control of fractional-order (~3.6e-04 vs. 47.4). This proposed NMPC of fractional-order can be used for other models of epidemics.https://doi.org/10.1177/11795972251321306
spellingShingle Mohadeseh Najafi
Hamidreza Mortazavy Beni
Ashkan Heydarian
Samaneh Sadat Sajjadi
Ahmad Hajipour
Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
Biomedical Engineering and Computational Biology
title Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
title_full Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
title_fullStr Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
title_full_unstemmed Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
title_short Is it Curbing-spread of SARS-CoV-2 Variants by Considering Non-linear Predictive Control?
title_sort is it curbing spread of sars cov 2 variants by considering non linear predictive control
url https://doi.org/10.1177/11795972251321306
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