Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE

Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE

Abstract Objective METTL3, an m6A methyltransferase, enhances germinal center responses. This study explores its role in lupus B cells and its impact on B-cell activation. Methods METTL3 and m6A levels in B cells from systemic lupus erythematosus (SLE) patients and lupus-prone mice were analyzed usi...

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Bibliographic Details
Main Authors: Yiying Yang, Ying Zhang, Shasha Xie, Ke Liu, Meidong Liu, Yisha Li, Hui Luo, Xiaoxia Zuo, Huali Zhang, Muyao Guo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
B cells
SLE
M6A
METTL3
PAX5
Online Access:https://doi.org/10.1186/s10020-025-01295-2
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