Living donor uterus transplant research project in Singapore: Progress of the first case
Abstract Introduction To report the progress of the human living uterus transplant research project in Singapore. Material and Methods The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams. Ethics approval was obtained from the SingHealth C...
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Wiley
2025-03-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.15048 |
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| author | Hak Koon Tan Terence Y. S. Kee Bien Keem Tan Pernilla Dahm‐Kähler Niclas Kvarnström Ravinchandran Nadarajah Khong Yik Chew Ban Hock Tan Tew Hong Ho Lay Kok Tan Yin Ru Tan Sobhana Thangaraju Loong Tat Wong John S. E. Lee Leslie E. C. Lim Shing Lih Wong Lay Guat Ng Yan Mee Law Crystal Lim Prema Raj Jeyaraj Ruban Poopalingam Mats Brännström |
| author_facet | Hak Koon Tan Terence Y. S. Kee Bien Keem Tan Pernilla Dahm‐Kähler Niclas Kvarnström Ravinchandran Nadarajah Khong Yik Chew Ban Hock Tan Tew Hong Ho Lay Kok Tan Yin Ru Tan Sobhana Thangaraju Loong Tat Wong John S. E. Lee Leslie E. C. Lim Shing Lih Wong Lay Guat Ng Yan Mee Law Crystal Lim Prema Raj Jeyaraj Ruban Poopalingam Mats Brännström |
| author_sort | Hak Koon Tan |
| collection | DOAJ |
| description | Abstract Introduction To report the progress of the human living uterus transplant research project in Singapore. Material and Methods The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams. Ethics approval was obtained from the SingHealth Centralised Institutional Review Board, the SingHealth Transplant and the Singapore General Hospital Biomedical Ethics Committee to perform 5 uterus transplant procedures in a collaborative multi‐site research study at the Singapore General Hospital. Regulatory approval was obtained from the Ministry of Health, Singapore. A suitable recipient–donor pair was identified. The living donor was the perimenopausal mother‐in‐law of the recipient who had Mayer–Rokitansky–Kuster–Hauser syndrome. They underwent the requisite matching process as well as robust medical, psychiatric and psychosocial assessments. The recipient then underwent in vitro fertilization (IVF) treatment resulting in 6 frozen blastocysts. Preparations were made for the transplant surgery on 25 November 2023 in Singapore General Hospital, aided by the 3 Uterus transplant experts from the Swedish Team, for whom temporary registration was granted by the Singapore Medical Council. Results This first uterus transplant procedure involved an operative time of 10 h and 30 min for the donor. The synchronized recipient surgery lasted 6 h and 20 min. Surgery was by midline laparotomy in both the living donor and recipient. The total warm ischemic time of the graft was 45 min, and the cold ischemic time was 1 h 45 min (total ischemic time 2 h 30 min). The patient's first menstruation occurred 38 days after the uterus transplant procedure. Cytomegalovirus infection was detected 6 weeks postoperatively for which she was aggressively treated. Serial cervical biopsies showed no rejection and Doppler ultrasound of the transplanted uterus showed good uterine blood flow. Conclusions To date the Living Donor Uterus Transplant Research Project in Singapore has progressed with a uterus transplant surgery involving a living donor performed by a multidisciplinary team. The recipient had a menstrual period 38 days postoperatively. Further study of the outcomes from this procedure will inform the safety and efficacy of uterus transplant in the Singapore context. |
| format | Article |
| id | doaj-art-a7e628ddb3064eb0951521e269ea91d2 |
| institution | Kabale University |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2025-03-01 |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-a7e628ddb3064eb0951521e269ea91d22025-08-20T03:31:00ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122025-03-01104354855810.1111/aogs.15048Living donor uterus transplant research project in Singapore: Progress of the first caseHak Koon Tan0Terence Y. S. Kee1Bien Keem Tan2Pernilla Dahm‐Kähler3Niclas Kvarnström4Ravinchandran Nadarajah5Khong Yik Chew6Ban Hock Tan7Tew Hong Ho8Lay Kok Tan9Yin Ru Tan10Sobhana Thangaraju11Loong Tat Wong12John S. E. Lee13Leslie E. C. Lim14Shing Lih Wong15Lay Guat Ng16Yan Mee Law17Crystal Lim18Prema Raj Jeyaraj19Ruban Poopalingam20Mats Brännström21Department of Obstetrics and Gynaecology Singapore General Hospital Singapore SingaporeDepartment of Renal Medicine Singapore General Hospital Singapore SingaporeDepartment of Plastic, Reconstructive & Aesthetic Surgery Singapore General Hospital Singapore SingaporeSahlgrenska Academy University of Gothenburg Gothenburg SwedenSahlgrenska Academy University of Gothenburg Gothenburg SwedenDepartment of Obstetrics and Gynaecology Singapore General Hospital Singapore SingaporeDepartment of Plastic, Reconstructive & Aesthetic Surgery Singapore General Hospital Singapore SingaporeDepartment of Infectious Diseases Singapore General Hospital Singapore SingaporeDepartment of Obstetrics and Gynaecology Singapore General Hospital Singapore SingaporeDepartment of Obstetrics and Gynaecology Singapore General Hospital Singapore SingaporeDepartment of Obstetrics and Gynaecology Singapore General Hospital Singapore SingaporeDepartment of Renal Medicine Singapore General Hospital Singapore SingaporeDepartment of Anaesthesiology Singapore General Hospital Singapore SingaporeDepartment of Anaesthesiology Singapore General Hospital Singapore SingaporeDepartment of Psychiatry Singapore General Hospital Singapore SingaporeDepartment of Pathology Singapore General Hospital Singapore SingaporeDepartment of Urology Singapore General Hospital Singapore SingaporeDepartment of Diagnostic Radiology Singapore General Hospital Singapore SingaporeDepartment of Medical Social Services Singapore General Hospital Singapore SingaporeDepartment of Hepatobiliary and Transplant Surgery Singapore General Hospital Singapore SingaporeDepartment of Anaesthesiology Singapore General Hospital Singapore SingaporeSahlgrenska Academy University of Gothenburg Gothenburg SwedenAbstract Introduction To report the progress of the human living uterus transplant research project in Singapore. Material and Methods The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams. Ethics approval was obtained from the SingHealth Centralised Institutional Review Board, the SingHealth Transplant and the Singapore General Hospital Biomedical Ethics Committee to perform 5 uterus transplant procedures in a collaborative multi‐site research study at the Singapore General Hospital. Regulatory approval was obtained from the Ministry of Health, Singapore. A suitable recipient–donor pair was identified. The living donor was the perimenopausal mother‐in‐law of the recipient who had Mayer–Rokitansky–Kuster–Hauser syndrome. They underwent the requisite matching process as well as robust medical, psychiatric and psychosocial assessments. The recipient then underwent in vitro fertilization (IVF) treatment resulting in 6 frozen blastocysts. Preparations were made for the transplant surgery on 25 November 2023 in Singapore General Hospital, aided by the 3 Uterus transplant experts from the Swedish Team, for whom temporary registration was granted by the Singapore Medical Council. Results This first uterus transplant procedure involved an operative time of 10 h and 30 min for the donor. The synchronized recipient surgery lasted 6 h and 20 min. Surgery was by midline laparotomy in both the living donor and recipient. The total warm ischemic time of the graft was 45 min, and the cold ischemic time was 1 h 45 min (total ischemic time 2 h 30 min). The patient's first menstruation occurred 38 days after the uterus transplant procedure. Cytomegalovirus infection was detected 6 weeks postoperatively for which she was aggressively treated. Serial cervical biopsies showed no rejection and Doppler ultrasound of the transplanted uterus showed good uterine blood flow. Conclusions To date the Living Donor Uterus Transplant Research Project in Singapore has progressed with a uterus transplant surgery involving a living donor performed by a multidisciplinary team. The recipient had a menstrual period 38 days postoperatively. Further study of the outcomes from this procedure will inform the safety and efficacy of uterus transplant in the Singapore context.https://doi.org/10.1111/aogs.15048absolute uterine factor infertilityliving transplantmultidisciplinary teamSingaporeuterus transplantation |
| spellingShingle | Hak Koon Tan Terence Y. S. Kee Bien Keem Tan Pernilla Dahm‐Kähler Niclas Kvarnström Ravinchandran Nadarajah Khong Yik Chew Ban Hock Tan Tew Hong Ho Lay Kok Tan Yin Ru Tan Sobhana Thangaraju Loong Tat Wong John S. E. Lee Leslie E. C. Lim Shing Lih Wong Lay Guat Ng Yan Mee Law Crystal Lim Prema Raj Jeyaraj Ruban Poopalingam Mats Brännström Living donor uterus transplant research project in Singapore: Progress of the first case Acta Obstetricia et Gynecologica Scandinavica absolute uterine factor infertility living transplant multidisciplinary team Singapore uterus transplantation |
| title | Living donor uterus transplant research project in Singapore: Progress of the first case |
| title_full | Living donor uterus transplant research project in Singapore: Progress of the first case |
| title_fullStr | Living donor uterus transplant research project in Singapore: Progress of the first case |
| title_full_unstemmed | Living donor uterus transplant research project in Singapore: Progress of the first case |
| title_short | Living donor uterus transplant research project in Singapore: Progress of the first case |
| title_sort | living donor uterus transplant research project in singapore progress of the first case |
| topic | absolute uterine factor infertility living transplant multidisciplinary team Singapore uterus transplantation |
| url | https://doi.org/10.1111/aogs.15048 |
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