Metabolic reprogramming in melanoma therapy
Abstract Melanoma, a deadly and aggressive cancer, exhibits significant metabolic reprogramming that supports energy production, biosynthesis, and tumor progression. This metabolic adaptation drives melanoma growth, proliferation, metastasis, and therapy resistance, highlighting its potential as a p...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02617-3 |
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| _version_ | 1849769662823268352 |
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| author | Dongliang Shen Lu Zhang Shun Li Liling Tang |
| author_facet | Dongliang Shen Lu Zhang Shun Li Liling Tang |
| author_sort | Dongliang Shen |
| collection | DOAJ |
| description | Abstract Melanoma, a deadly and aggressive cancer, exhibits significant metabolic reprogramming that supports energy production, biosynthesis, and tumor progression. This metabolic adaptation drives melanoma growth, proliferation, metastasis, and therapy resistance, highlighting its potential as a promising target for therapeutic intervention. This review focuses on the latest studies elucidating metabolic pathways involved in melanoma progression, therapeutic response, and resistance. Additionally, the potential of targeting metabolic pathways–either alone or in combination with established therapeutic inhibitors–to block disease progression in melanoma is also discussed. Such insights might improve our understanding of metabolic pathways in melanoma development and foster advancements in melanoma therapy. |
| format | Article |
| id | doaj-art-a7e002b516ae4f1297014774a2777825 |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-a7e002b516ae4f1297014774a27778252025-08-20T03:03:20ZengNature Publishing GroupCell Death Discovery2058-77162025-07-011111910.1038/s41420-025-02617-3Metabolic reprogramming in melanoma therapyDongliang Shen0Lu Zhang1Shun Li2Liling Tang3Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing UniversityKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing UniversityDepartment of Immunology, School of Basic Medical Sciences, Chengdu Medical CollegeKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing UniversityAbstract Melanoma, a deadly and aggressive cancer, exhibits significant metabolic reprogramming that supports energy production, biosynthesis, and tumor progression. This metabolic adaptation drives melanoma growth, proliferation, metastasis, and therapy resistance, highlighting its potential as a promising target for therapeutic intervention. This review focuses on the latest studies elucidating metabolic pathways involved in melanoma progression, therapeutic response, and resistance. Additionally, the potential of targeting metabolic pathways–either alone or in combination with established therapeutic inhibitors–to block disease progression in melanoma is also discussed. Such insights might improve our understanding of metabolic pathways in melanoma development and foster advancements in melanoma therapy.https://doi.org/10.1038/s41420-025-02617-3 |
| spellingShingle | Dongliang Shen Lu Zhang Shun Li Liling Tang Metabolic reprogramming in melanoma therapy Cell Death Discovery |
| title | Metabolic reprogramming in melanoma therapy |
| title_full | Metabolic reprogramming in melanoma therapy |
| title_fullStr | Metabolic reprogramming in melanoma therapy |
| title_full_unstemmed | Metabolic reprogramming in melanoma therapy |
| title_short | Metabolic reprogramming in melanoma therapy |
| title_sort | metabolic reprogramming in melanoma therapy |
| url | https://doi.org/10.1038/s41420-025-02617-3 |
| work_keys_str_mv | AT dongliangshen metabolicreprogramminginmelanomatherapy AT luzhang metabolicreprogramminginmelanomatherapy AT shunli metabolicreprogramminginmelanomatherapy AT lilingtang metabolicreprogramminginmelanomatherapy |