Fe3O4@SiO2-SnCl4-promoted synthesis, cytotoxic evaluation, molecular docking, and MD simulation of some indenopyrido[2,3-d]pyrimidine derivatives

Fe3O4@SiO2-SnCl4-promoted synthesis, cytotoxic evaluation, molecular docking, and MD simulation of some indenopyrido[2,3-d]pyrimidine derivatives

Abstract In this study, an efficient and environmentally friendly method for the one-pot synthesis of indenopyrido[2,3-d]pyrimidine derivatives was developed using Fe3O4@SiO2-SnCl4 nanoparticles as a catalyst. Indenopyrido[2,3-d]pyrimidines (4a-4j) were synthesized via three-component couplings of 6...

Full description

Saved in:

Bibliographic Details
Main Authors:	Leila Emami, Ladan Baziyar, Al-Anood Mohammad Al-Dies, Sara Sadeghian, Bi Bi Fatemeh Mirjalili, Zeinab Faghih, Sajad Khorasani, Leila Zamani, Soghra Khabnadideh
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	BMC Chemistry
Subjects:	Indenopyrido[2,3-d]pyrimidine Cytotoxic activity Molecular docking MD Simulation
Online Access:	https://doi.org/10.1186/s13065-025-01489-z
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design, synthesis, in silico studies and antiproliferative evaluation of some novel hybrids of pyrimidine-morpholine
by: Elaheh Ataollahi, et al.
Published: (2025-02-01)

Design, synthesis, biological evaluation and computational studies of 4-Aminopiperidine-3, 4-dihyroquinazoline-2-uracil derivatives as promising antidiabetic agents
by: Ladan Baziar, et al.
Published: (2024-11-01)

A Review on Current Synthetic Methods of 4-Aminoquinazoline Derivatives
by: Soghra Khabnadideh, et al.
Published: (2022-01-01)

Synthesis and Application of SnCl2.H2O/ZnO Photoanodes
by: Vanja Fontenele Nunes, et al.
Published: (2025-05-01)

SYNTHESIS OF 4,4'-BIS-PYRIMIDINES AND SOME RELATED BIS-FUSED PYRIMIDINES
Published: (1995-08-01)

(Cy2NH2O2CPh)3(SnCl4)2 AND (SnBu2)4(O2CPh)16Cl6(OH)2(Cy2NH2)16: SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION
by: Dinora De Barros, et al.
Published: (2011-09-01)

Design, synthesis, biological assessments and computational studies of 3-substituted phenyl quinazolinone derivatives as promising anti-cancer agents
by: Maryam Moghtader Mansouri, et al.
Published: (2025-05-01)

Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives
by: Khammas et al.
Published: (2019-12-01)

2Cu(en)2Cl2. 4SnPh2Cl2.SnCl4 and Cu(en)3CuCl4SnPh3Cl: Synthesis and Spectroscopic Studies
by: Seck Seydi Mansour Sy, et al.
Published: (2010-12-01)

TOXICITY AND ANTIMICROBIAL ACTIVITY OF 6-CHLORO-2,4-DIAMINO- PYRIMIDINE
by: Rana A. Faaz, et al.
Published: (2015-06-01)

5-(2-Carboxyethenyl)-Isatin Derivatives as Anticancer Agents: QSAR, Molecular Docking and Molecular Dynamic Simulation Analysis
by: Leila Emami, et al.
Published: (2021-05-01)

Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs
by: Hailong Yang, et al.
Published: (2025-05-01)

2-(Heptylthio)pyrimidine-4,6-diamine
by: Gulrukh Salieva, et al.
Published: (2025-02-01)

An improved procedure for synthesis of lenalidomide as an active pharmaceutical ingredient
by: Elaheh Ataollahi, et al.
Published: (2025-09-01)

Preparation of a new reusable magnetic organocatalyst to synthesis of polyhydroquinoline derivatives as cytotoxic Agents: Synthesis and biological evaluation
by: Leila Amiri-Zirtol, et al.
Published: (2024-11-01)

SELECTIVE CYCLIZATION OF 2-PROPARGYLTHIO-6-METHYL-PYRIMIDIN- 4(1 H)-ONE TO THIAZOLO [3,2-a] PYRIMIDIN 7-ONE
Published: (1998-03-01)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
by: Asmaa A. Mandour, et al.
Published: (2022-12-01)

New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies
by: Leila Emami, et al.
Published: (2025-05-01)

Nano-SiO2 catalyzed three-component preparations of pyrano[2,3-d]pyrimidines, 4H-chromenes, and dihydropyrano[3,2-c]chromenes
by: Ebrahim Mollashahi, et al.
Published: (2018-01-01)

Evaluation of Nano-Fe3O4 as a Green Catalyst for the Synthesis of Mono, bis and tris Diindolyl Methanes
by: Leila Zare, et al.
Published: (2012-01-01)

Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction
by: Razieh Sabet, et al.
Published: (2024-12-01)

4', 5'-(1 6,17-epi-Androsteno-)pyrido [2', 3'-d]pyrimidine
by: Gerhard Bouchon, et al.
Published: (1973-04-01)

Synthesis, properties, and applications of Fe3O4 and Fe3O4-based nanocomposites: A review
by: Syed Izaz Ali Shah, et al.
Published: (2025-06-01)

Synthesis of some pyrimidine derivatives from-4- acetyl pyridine
by: Reem. S. Najem
Published: (2018-05-01)

Crystal structure of (E)-2,2′,3,3′-tetrahydro-[1,1′-biindenylidene]-4,4′-diol, C18H16O2
by: Hao Yuwei, et al.
Published: (2025-02-01)

INTERACTIONS BETWEEN (Me[sub]4[/sub]N)[sub]2[/sub](C[sub]2[/sub]O[sub]4[/sub])[sub]2[/sub]SnPh2•H[sub]2[/sub]O AND SnC[sub]l2[/sub]•2H[sub]2[/sub]O: (Me[sub]4[/sub]N)[sub]2[/sub](C[sub]2[/sub]O[sub]4[/sub])[sub]2[/sub]SnPh[sub]2[/sub]•2SnCl[sub]4[/sub] OR (Me[sub]4[/sub]N)[sub]2[/sub](C[sub]2[/sub]O[sub]4[/sub])[sub]2[/sub]SnCl[sub]2[/sub]•2SnPhCl[sub]3[/sub] ? THE MÖSSBAUER EFFECT SOLUTION
by: Libasse Diop, et al.
Published: (2010-10-01)

Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors
by: Nicoletta Brindani, et al.
Published: (2025-06-01)

The crystal structure of 4-(3-bromophenyl)pyrimidin-2-amine, C10H8BrN3
by: Khan Arshad, et al.
Published: (2021-09-01)

Crystal structure of poly[(μ 3-3,3″,5,5″-tetrafluoro-(1,1′:4′,1″-terphenyl)-4,4″-dicarboxylate-κ 3 O,O′:O″)-(μ 4-3,3″,5,5″-tetrafluoro-(1,1′:4′,1″-terphenyl)-4,4″-dicarboxylate-κ 4 O,O′,O″,O‴)-dicadmium(II)]dimethylformamide solvate, C47H30Cd2F8N3O12
by: Jing Hao, et al.
Published: (2025-08-01)

Applicability, adsorbent chitosan@Fe2 (MoO4)3 nanocomposite for removal of textile reactive red198 dye from wastewater
by: Elham Pournamdari, et al.
Published: (2024-01-01)

4-phenyl-5-((pyrimidin-2-ylthio)methyl)-1,2,4-triazole-3-thiol as a platform for the synthesis of unsymmetrical disulfides
by: Yu. V. Karpenko, et al.
Published: (2025-03-01)

Physical character conductivity of system, including ethylene-propylene copolymer and SnCl<sub>2</sub>
by: N. N. Komova, et al.
Published: (2006-10-01)

Multicomponent, Solvent-Free Synthesis of 4-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidines Derivatives
by: Fatima Belhadj, et al.
Published: (2023-11-01)

Determination of the Anti-Escherichial Activity of the Pyrimidine Derivative 3-[2-[(4,6-dimethylpyrimidin-2- yl)amino]-2-oxoethyl]quinazolin-4(3H)-one
by: A. A. Tsibizova, et al.
Published: (2023-12-01)

Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
by: Yuancheng Mao, et al.
Published: (2022-12-01)

3D QSAR of Pyrrolo Pyrimidine and Thieno Pyrimidines as Human Thymidylate Synthase Inhibitors
by: K. Meena Kumari, et al.
Published: (2012-01-01)

Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives
by: Manal M. El-Shahawi, et al.
Published: (2017-01-01)

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M
by: Ahmed A. Gaber, et al.
Published: (2022-12-01)

Exploring 4,7-Disubstituted Pyrimido[4,5-<i>d</i>]pyrimidines as Antiviral and Anticancer Agents
by: Eleftheria A. Georgiou, et al.
Published: (2024-11-01)

Synthesis of New Pyrazolo[1,5-a]pyrimidine, Triazolo[4,3-a]pyrimidine Derivatives, and Thieno[2,3-b]pyridine Derivatives from Sodium 3-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate
by: Abdou O. Abdelhamid, et al.
Published: (2013-01-01)