The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice
Abstract Noise-induced hearing loss (NIHL) is a widespread auditory disorder in industrialized nations, posing significant global and domestic health concerns. Despite its prevalence, the mechanisms underlying NIHL remain poorly understood, hindering the development of effective therapeutic interven...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-07669-0 |
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| author | Kasumi Sato Katherine Araya Cathryn Wu Emily Dong Riley Watson Manjit Maskey Chau D. Nguyen Kamil Khanipov Qing Yang Zizhen Wu |
| author_facet | Kasumi Sato Katherine Araya Cathryn Wu Emily Dong Riley Watson Manjit Maskey Chau D. Nguyen Kamil Khanipov Qing Yang Zizhen Wu |
| author_sort | Kasumi Sato |
| collection | DOAJ |
| description | Abstract Noise-induced hearing loss (NIHL) is a widespread auditory disorder in industrialized nations, posing significant global and domestic health concerns. Despite its prevalence, the mechanisms underlying NIHL remain poorly understood, hindering the development of effective therapeutic interventions. Emerging evidence from clinical and animal studies suggests a potential relationship between altered gut microbiota and hearing loss, although causality remains unclear. In this study, we investigated the role of postnatal microbial signals in NIHL pathogenesis using acute noise exposure models in C57BL/6 mice. Our findings indicate that acute noise exposure does not significantly alter gut microbiota composition in this strain and that microbiota depletion does not confer protection against hearing loss following acute acoustic trauma. These results suggest no link between gut microbiota and acute NIHL in C57BL/6 mice. |
| format | Article |
| id | doaj-art-a7dfcb06a5b64b7ca107468c8c5840ec |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a7dfcb06a5b64b7ca107468c8c5840ec2025-08-20T04:01:34ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-07669-0The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 miceKasumi Sato0Katherine Araya1Cathryn Wu2Emily Dong3Riley Watson4Manjit Maskey5Chau D. Nguyen6Kamil Khanipov7Qing Yang8Zizhen Wu9Department of Neurobiology, University of Texas Medical BranchDepartment of Pharmacology & Toxicology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchDepartment of Pharmacology & Toxicology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchDepartment of Pharmacology & Toxicology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchDepartment of Neurobiology, University of Texas Medical BranchAbstract Noise-induced hearing loss (NIHL) is a widespread auditory disorder in industrialized nations, posing significant global and domestic health concerns. Despite its prevalence, the mechanisms underlying NIHL remain poorly understood, hindering the development of effective therapeutic interventions. Emerging evidence from clinical and animal studies suggests a potential relationship between altered gut microbiota and hearing loss, although causality remains unclear. In this study, we investigated the role of postnatal microbial signals in NIHL pathogenesis using acute noise exposure models in C57BL/6 mice. Our findings indicate that acute noise exposure does not significantly alter gut microbiota composition in this strain and that microbiota depletion does not confer protection against hearing loss following acute acoustic trauma. These results suggest no link between gut microbiota and acute NIHL in C57BL/6 mice.https://doi.org/10.1038/s41598-025-07669-0Noise-induced hearing lossAcuteABRGut microbiotaGerm-freeC57BL/6 |
| spellingShingle | Kasumi Sato Katherine Araya Cathryn Wu Emily Dong Riley Watson Manjit Maskey Chau D. Nguyen Kamil Khanipov Qing Yang Zizhen Wu The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice Scientific Reports Noise-induced hearing loss Acute ABR Gut microbiota Germ-free C57BL/6 |
| title | The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice |
| title_full | The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice |
| title_fullStr | The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice |
| title_full_unstemmed | The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice |
| title_short | The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice |
| title_sort | gut microbiota is not linked to acute noise induced hearing loss in c57bl 6 mice |
| topic | Noise-induced hearing loss Acute ABR Gut microbiota Germ-free C57BL/6 |
| url | https://doi.org/10.1038/s41598-025-07669-0 |
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