Selenium in cancer management: exploring the therapeutic potential
Selenium (Se) is important and plays significant roles in many biological processes or physiological activities. Prolonged selenium deficiency has been conclusively linked to an elevated risk of various diseases, including but not limited to cancer, cardiovascular disease, inflammatory bowel disease...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1490740/full |
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| author | Lingwen He Lu Zhang Yulong Peng Zhijun He Zhijun He |
| author_facet | Lingwen He Lu Zhang Yulong Peng Zhijun He Zhijun He |
| author_sort | Lingwen He |
| collection | DOAJ |
| description | Selenium (Se) is important and plays significant roles in many biological processes or physiological activities. Prolonged selenium deficiency has been conclusively linked to an elevated risk of various diseases, including but not limited to cancer, cardiovascular disease, inflammatory bowel disease, Keshan disease, and acquired immunodeficiency syndrome. The intricate relationship between selenium status and health outcomes is believed to be characterized by a non-linear U-shaped dose-response curve. This review delves into the significance of maintaining optimal selenium levels and the detrimental effects that can arise from selenium deficiency. Of particular interest is the important role that selenium plays in both prevention and treatment of cancer. Finally, this review also explores the diverse classes of selenium entities, encompassing selenoproteins, selenium compounds and selenium nanoparticles, while examining the mechanisms and molecular targets of their anticancer efficacy. |
| format | Article |
| id | doaj-art-a7db30e3a35646d38f90194372445778 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-a7db30e3a35646d38f901943724457782025-01-07T05:23:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14907401490740Selenium in cancer management: exploring the therapeutic potentialLingwen He0Lu Zhang1Yulong Peng2Zhijun He3Zhijun He4Department of Oncology, Dongguan Songshan Lake Tungwah Hospital, Dongguan, ChinaDepartment of Oncology, Dongguan Songshan Lake Tungwah Hospital, Dongguan, ChinaDepartment of Oncology, Dongguan Tungwah Hospital, Dongguan, ChinaSchool of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan, ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, ChinaSelenium (Se) is important and plays significant roles in many biological processes or physiological activities. Prolonged selenium deficiency has been conclusively linked to an elevated risk of various diseases, including but not limited to cancer, cardiovascular disease, inflammatory bowel disease, Keshan disease, and acquired immunodeficiency syndrome. The intricate relationship between selenium status and health outcomes is believed to be characterized by a non-linear U-shaped dose-response curve. This review delves into the significance of maintaining optimal selenium levels and the detrimental effects that can arise from selenium deficiency. Of particular interest is the important role that selenium plays in both prevention and treatment of cancer. Finally, this review also explores the diverse classes of selenium entities, encompassing selenoproteins, selenium compounds and selenium nanoparticles, while examining the mechanisms and molecular targets of their anticancer efficacy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1490740/fullseleniumcancerselenoproteinselenium compoundsselenium nanoparticles |
| spellingShingle | Lingwen He Lu Zhang Yulong Peng Zhijun He Zhijun He Selenium in cancer management: exploring the therapeutic potential Frontiers in Oncology selenium cancer selenoprotein selenium compounds selenium nanoparticles |
| title | Selenium in cancer management: exploring the therapeutic potential |
| title_full | Selenium in cancer management: exploring the therapeutic potential |
| title_fullStr | Selenium in cancer management: exploring the therapeutic potential |
| title_full_unstemmed | Selenium in cancer management: exploring the therapeutic potential |
| title_short | Selenium in cancer management: exploring the therapeutic potential |
| title_sort | selenium in cancer management exploring the therapeutic potential |
| topic | selenium cancer selenoprotein selenium compounds selenium nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1490740/full |
| work_keys_str_mv | AT lingwenhe seleniumincancermanagementexploringthetherapeuticpotential AT luzhang seleniumincancermanagementexploringthetherapeuticpotential AT yulongpeng seleniumincancermanagementexploringthetherapeuticpotential AT zhijunhe seleniumincancermanagementexploringthetherapeuticpotential AT zhijunhe seleniumincancermanagementexploringthetherapeuticpotential |