Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease
The glial lymphatic system (GLS) is responsible for removing metabolic waste and aberrantly deposited substances from brain by exchanging materials with interstitial fluid (ISF), thereby maintaining cerebral homeostasis. Dysfunction in this system can result in the abnormal accumulation of amyloid-b...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025001893 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850158515609403392 |
|---|---|
| author | Feiyue Mi Xiaoyan Yang Xueyan Huang Gaoqiang Xu Dongfeng Pan Changyin Yu |
| author_facet | Feiyue Mi Xiaoyan Yang Xueyan Huang Gaoqiang Xu Dongfeng Pan Changyin Yu |
| author_sort | Feiyue Mi |
| collection | DOAJ |
| description | The glial lymphatic system (GLS) is responsible for removing metabolic waste and aberrantly deposited substances from brain by exchanging materials with interstitial fluid (ISF), thereby maintaining cerebral homeostasis. Dysfunction in this system can result in the abnormal accumulation of amyloid-beta (Aβ) and tau proteins, leading to cognitive impairments. Recent advancements in neuroimaging have enhanced the evaluation of GLS function, forming a vital component of Alzheimer's disease (AD) diagnostics. This article offers a comprehensive overview of the imaging performance of various methods used to visualize the glial lymphatic system in Alzheimer's disease (AD), highlighting their respective advantages and limitations. |
| format | Article |
| id | doaj-art-a7d652d8937546dca2bde35280ff5b44 |
| institution | OA Journals |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-a7d652d8937546dca2bde35280ff5b442025-08-20T02:23:51ZengElsevierBrain Research Bulletin1873-27472025-07-0122711137710.1016/j.brainresbull.2025.111377Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's DiseaseFeiyue Mi0Xiaoyan Yang1Xueyan Huang2Gaoqiang Xu3Dongfeng Pan4Changyin Yu5Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China; Corresponding authors.Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China; Corresponding authors.The glial lymphatic system (GLS) is responsible for removing metabolic waste and aberrantly deposited substances from brain by exchanging materials with interstitial fluid (ISF), thereby maintaining cerebral homeostasis. Dysfunction in this system can result in the abnormal accumulation of amyloid-beta (Aβ) and tau proteins, leading to cognitive impairments. Recent advancements in neuroimaging have enhanced the evaluation of GLS function, forming a vital component of Alzheimer's disease (AD) diagnostics. This article offers a comprehensive overview of the imaging performance of various methods used to visualize the glial lymphatic system in Alzheimer's disease (AD), highlighting their respective advantages and limitations.http://www.sciencedirect.com/science/article/pii/S0361923025001893Alzheimer's diseaseGlial lymphatic systemMRIPET-CT |
| spellingShingle | Feiyue Mi Xiaoyan Yang Xueyan Huang Gaoqiang Xu Dongfeng Pan Changyin Yu Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease Brain Research Bulletin Alzheimer's disease Glial lymphatic system MRI PET-CT |
| title | Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease |
| title_full | Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease |
| title_fullStr | Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease |
| title_full_unstemmed | Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease |
| title_short | Advances in diagnostic imaging of the glial lymphatic system in Alzheimer's Disease |
| title_sort | advances in diagnostic imaging of the glial lymphatic system in alzheimer s disease |
| topic | Alzheimer's disease Glial lymphatic system MRI PET-CT |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025001893 |
| work_keys_str_mv | AT feiyuemi advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease AT xiaoyanyang advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease AT xueyanhuang advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease AT gaoqiangxu advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease AT dongfengpan advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease AT changyinyu advancesindiagnosticimagingofthegliallymphaticsysteminalzheimersdisease |