No synergistic effect of subtherapeutic doses of donepezil and EVP‐6124 in healthy elderly subjects in a scopolamine challenge model

Abstract Introduction Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large‐scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting. The present exploratory study is designed to deter...

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Bibliographic Details
Main Authors: Anne Catrien Baakman, Ricardo Alvarez‐Jimenez, Gordon Loewen, Marieke L. deKam, Karen Broekhuizen, Dana C. Hilt, Geert Jan Groeneveld
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
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Online Access:https://doi.org/10.1016/j.trci.2019.02.002
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