Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy
This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scin...
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Via Medica
2025-08-01
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| Series: | Nuclear Medicine Review |
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| Online Access: | https://journals.viamedica.pl/nuclear_medicine_review/article/view/106313 |
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| author | Nasrin Raeisi Amin Saber Tanha Salman Soltani Ali zare Atena Aghaee |
| author_facet | Nasrin Raeisi Amin Saber Tanha Salman Soltani Ali zare Atena Aghaee |
| author_sort | Nasrin Raeisi |
| collection | DOAJ |
| description | This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scintigraphy showed photopenic areas and accumulation in a compressed gallbladder, showing an intriguing pattern. A comprehensive surgical resection of the tumor involving the right kidney, adrenal gland, ascending and a portion of transverse colon and liver was successfully performed, and the pathological evaluation confirmed the diagnosis of clear cell renal cell carcinoma (ccRCC). This case represents the pioneering application of [99mTc]Tc-FAPI-46 scintigraphy in ccRCC with sarcomatoid features, demonstrating a lack of avidity. |
| format | Article |
| id | doaj-art-a7cf8febf8da422b8d8518161ce3c891 |
| institution | Kabale University |
| issn | 1506-9680 1644-4345 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Nuclear Medicine Review |
| spelling | doaj-art-a7cf8febf8da422b8d8518161ce3c8912025-08-21T07:22:29ZengVia MedicaNuclear Medicine Review1506-96801644-43452025-08-0128Continuous Publishing10.5603/nmr.106313Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphyNasrin Raeisi0Amin Saber Tanha1https://orcid.org/0009-0008-0290-0412Salman Soltani2Ali zare3Atena Aghaee4Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranThis report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scintigraphy showed photopenic areas and accumulation in a compressed gallbladder, showing an intriguing pattern. A comprehensive surgical resection of the tumor involving the right kidney, adrenal gland, ascending and a portion of transverse colon and liver was successfully performed, and the pathological evaluation confirmed the diagnosis of clear cell renal cell carcinoma (ccRCC). This case represents the pioneering application of [99mTc]Tc-FAPI-46 scintigraphy in ccRCC with sarcomatoid features, demonstrating a lack of avidity.https://journals.viamedica.pl/nuclear_medicine_review/article/view/106313renal cell carcinomaFAPIurologic neoplasmoncologytheranostics |
| spellingShingle | Nasrin Raeisi Amin Saber Tanha Salman Soltani Ali zare Atena Aghaee Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy Nuclear Medicine Review renal cell carcinoma FAPI urologic neoplasm oncology theranostics |
| title | Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy |
| title_full | Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy |
| title_fullStr | Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy |
| title_full_unstemmed | Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy |
| title_short | Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy |
| title_sort | fibroblast activation protein inhibitor fapi negative huge renal cell carcinoma demonstrating an intriguing pattern on 99mtc tc fapi 46 scintigraphy |
| topic | renal cell carcinoma FAPI urologic neoplasm oncology theranostics |
| url | https://journals.viamedica.pl/nuclear_medicine_review/article/view/106313 |
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