Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy
This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scin...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2025-08-01
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| Series: | Nuclear Medicine Review |
| Subjects: | |
| Online Access: | https://journals.viamedica.pl/nuclear_medicine_review/article/view/106313 |
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| Summary: | This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scintigraphy showed photopenic areas and accumulation in a compressed gallbladder, showing an intriguing pattern. A comprehensive surgical resection of the tumor involving the right kidney, adrenal gland, ascending and a portion of transverse colon and liver was successfully performed, and the pathological evaluation confirmed the diagnosis of clear cell renal cell carcinoma (ccRCC). This case represents the pioneering application of [99mTc]Tc-FAPI-46 scintigraphy in ccRCC with sarcomatoid features, demonstrating a lack of avidity. |
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| ISSN: | 1506-9680 1644-4345 |