Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water
Antibiotics and pesticides are widespread in most rivers and lakes due to the overuse of antibiotics and pesticides, but there are few methods for simultaneous analysis of antibiotics and pesticides in aquatic environments. To address this knowledge gap, a concise and sensitive analytical method is...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/6350669 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849698783261097984 |
|---|---|
| author | Xiang-Pu Zhang Shu Zhang Chun-Yan Xu Wei-Wei Li Hai-Bo Ling Yang Luo Kang Jian Tao Li Chuan Yi |
| author_facet | Xiang-Pu Zhang Shu Zhang Chun-Yan Xu Wei-Wei Li Hai-Bo Ling Yang Luo Kang Jian Tao Li Chuan Yi |
| author_sort | Xiang-Pu Zhang |
| collection | DOAJ |
| description | Antibiotics and pesticides are widespread in most rivers and lakes due to the overuse of antibiotics and pesticides, but there are few methods for simultaneous analysis of antibiotics and pesticides in aquatic environments. To address this knowledge gap, a concise and sensitive analytical method is proposed in which three classes of human and veterinary drugs (sulfonamides, macrolides, and hormones) and two classes of pesticides (organophosphorus and neonicotinoids) are simultaneously extracted and determined in surface water. The solid-phase extraction column with Cleanert PEP-2 was preconditioned sequentially with 6 mL of methanol, ultrapure water, and citric acid buffer (pH 3.0) each for simultaneous extraction and further purification. The forty-seven target analytes were analysed by LC-MS/MS in positive and negative ion modes. The LC separation was performed using a Sigma-Aldrich C18 column with 0.1% formic acid in water and acetonitrile as a gradient eluting mobile phase in positive ion mode. The internal standard method was used to overcome the inevitable matrix effects in LC-MS/MS analysis. The matrix effects of most target analytes were in the range of 27–151%. The recoveries of forty analytes in the three concentrations (10, 50, and 100 ng L−1) of surface water spiked samples ranged from 41 to 127%. The method quantitative limits of the analytes were in the range of 0.40–5.49 ng L−1. Application of the method to analyze samples in the eight runoff outlets of the Pearl River Delta showed that some antibiotics and pesticides were detected, and the concentration of parathion was as high as 154 ng L−1. A powerful tool for quickly and efficiently screening for contaminants in surface water has been presented. |
| format | Article |
| id | doaj-art-a7c7f64f8449433d8276a6788d4258a8 |
| institution | DOAJ |
| issn | 1687-8779 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-a7c7f64f8449433d8276a6788d4258a82025-08-20T03:18:48ZengWileyInternational Journal of Analytical Chemistry1687-87792023-01-01202310.1155/2023/6350669Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface WaterXiang-Pu Zhang0Shu Zhang1Chun-Yan Xu2Wei-Wei Li3Hai-Bo Ling4Yang Luo5Kang Jian6Tao Li7Chuan Yi8National Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionWuhan Ecological Environmental Monitoring CenterNational Key Laboratory of Environmental Health Risk Assessment for Environmental ProtectionAntibiotics and pesticides are widespread in most rivers and lakes due to the overuse of antibiotics and pesticides, but there are few methods for simultaneous analysis of antibiotics and pesticides in aquatic environments. To address this knowledge gap, a concise and sensitive analytical method is proposed in which three classes of human and veterinary drugs (sulfonamides, macrolides, and hormones) and two classes of pesticides (organophosphorus and neonicotinoids) are simultaneously extracted and determined in surface water. The solid-phase extraction column with Cleanert PEP-2 was preconditioned sequentially with 6 mL of methanol, ultrapure water, and citric acid buffer (pH 3.0) each for simultaneous extraction and further purification. The forty-seven target analytes were analysed by LC-MS/MS in positive and negative ion modes. The LC separation was performed using a Sigma-Aldrich C18 column with 0.1% formic acid in water and acetonitrile as a gradient eluting mobile phase in positive ion mode. The internal standard method was used to overcome the inevitable matrix effects in LC-MS/MS analysis. The matrix effects of most target analytes were in the range of 27–151%. The recoveries of forty analytes in the three concentrations (10, 50, and 100 ng L−1) of surface water spiked samples ranged from 41 to 127%. The method quantitative limits of the analytes were in the range of 0.40–5.49 ng L−1. Application of the method to analyze samples in the eight runoff outlets of the Pearl River Delta showed that some antibiotics and pesticides were detected, and the concentration of parathion was as high as 154 ng L−1. A powerful tool for quickly and efficiently screening for contaminants in surface water has been presented.http://dx.doi.org/10.1155/2023/6350669 |
| spellingShingle | Xiang-Pu Zhang Shu Zhang Chun-Yan Xu Wei-Wei Li Hai-Bo Ling Yang Luo Kang Jian Tao Li Chuan Yi Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water International Journal of Analytical Chemistry |
| title | Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water |
| title_full | Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water |
| title_fullStr | Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water |
| title_full_unstemmed | Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water |
| title_short | Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water |
| title_sort | liquid chromatography tandem mass spectrometry detection of human and veterinary drugs and pesticides in surface water |
| url | http://dx.doi.org/10.1155/2023/6350669 |
| work_keys_str_mv | AT xiangpuzhang liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT shuzhang liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT chunyanxu liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT weiweili liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT haiboling liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT yangluo liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT kangjian liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT taoli liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater AT chuanyi liquidchromatographytandemmassspectrometrydetectionofhumanandveterinarydrugsandpesticidesinsurfacewater |