Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors
Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two new cell-penetrating peptides - RB1 and RB3 - that...
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Main Authors: | Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/17111 |
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