Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection
Th1 derived cytokines IFN-γ and IL–2, Th2 cytokine IL–4, and ICAM–1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL–2, sIL–2 receptor, IL–4...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350050024366 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564701662281728 |
|---|---|
| author | E. Granot A. Tarcsafalvi S. Emre P. Sheiner S. Guy M. E. Schwartz P. Boros C. M. Miller |
| author_facet | E. Granot A. Tarcsafalvi S. Emre P. Sheiner S. Guy M. E. Schwartz P. Boros C. M. Miller |
| author_sort | E. Granot |
| collection | DOAJ |
| description | Th1 derived cytokines IFN-γ and IL–2, Th2 cytokine IL–4, and ICAM–1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL–2, sIL–2 receptor, IL–4 and ICAM–1 in 22 patients, in plasma samples obtained within 4h after liver perfusion (baseline) and between postoperative days (POD) 3–6. ICAM–1 and sIL–2R levels at POD 3–6 were significantly higher than at baseline but did not differ in presence or absence of rejection. Mean percentage increase of ICAM–1 levels was significantly lower in patients with Muromonab-C3 Orthoclone OKT3 (J.C. Health Care) (OKT3) whereas percentage increase of sIL–2R levels was higher in OKT3-treated patients. IFN-γ levels at POD 3–6 increased from baseline while IL–4 levels were unchanged. Levels of IFN-γ, IL–4 and their ratios did not correlate with rejection or immunosuppressive therapy. Thus, Th1/Th2 cytokine monitoring during the first week post-transplant does not predict early rejection and immunosuppressive therapy is the predominant factor affecting ICAM and sIL–2R levels after liver transplantation. |
| format | Article |
| id | doaj-art-a7a738cf487e4e6c89ecf0cfdbab13b0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a7a738cf487e4e6c89ecf0cfdbab13b02025-02-03T01:10:29ZengWileyMediators of Inflammation0962-93511466-18612000-01-0191353810.1080/09629350050024366Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejectionE. Granot0A. Tarcsafalvi1S. Emre2P. Sheiner3S. Guy4M. E. Schwartz5P. Boros6C. M. Miller7Department of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelDepartment of Paediatrics, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, IsraelTh1 derived cytokines IFN-γ and IL–2, Th2 cytokine IL–4, and ICAM–1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL–2, sIL–2 receptor, IL–4 and ICAM–1 in 22 patients, in plasma samples obtained within 4h after liver perfusion (baseline) and between postoperative days (POD) 3–6. ICAM–1 and sIL–2R levels at POD 3–6 were significantly higher than at baseline but did not differ in presence or absence of rejection. Mean percentage increase of ICAM–1 levels was significantly lower in patients with Muromonab-C3 Orthoclone OKT3 (J.C. Health Care) (OKT3) whereas percentage increase of sIL–2R levels was higher in OKT3-treated patients. IFN-γ levels at POD 3–6 increased from baseline while IL–4 levels were unchanged. Levels of IFN-γ, IL–4 and their ratios did not correlate with rejection or immunosuppressive therapy. Thus, Th1/Th2 cytokine monitoring during the first week post-transplant does not predict early rejection and immunosuppressive therapy is the predominant factor affecting ICAM and sIL–2R levels after liver transplantation.http://dx.doi.org/10.1080/09629350050024366 |
| spellingShingle | E. Granot A. Tarcsafalvi S. Emre P. Sheiner S. Guy M. E. Schwartz P. Boros C. M. Miller Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection Mediators of Inflammation |
| title | Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection |
| title_full | Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection |
| title_fullStr | Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection |
| title_full_unstemmed | Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection |
| title_short | Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection |
| title_sort | th1 th2 cytokines and icam 1 levels post liver transplant do not predict early rejection |
| url | http://dx.doi.org/10.1080/09629350050024366 |
| work_keys_str_mv | AT egranot th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT atarcsafalvi th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT semre th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT psheiner th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT sguy th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT meschwartz th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT pboros th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection AT cmmiller th1th2cytokinesandicam1levelspostlivertransplantdonotpredictearlyrejection |