Insights into the chemical basis for the impact of ceragenin and derivative compounds on the mechanical performance of medical adhesive formulations
Abstract An approach to reducing and preventing surgical site infections (SSI) is to incorporate an antimicrobial compound into the formulation of medical adhesives. Previous work showed that two ceragenin compounds, CSA-44 and CSA-131, did not negatively affect the shear strength of an adhesive for...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
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| Series: | Discover Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s42452-025-07483-3 |
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| Summary: | Abstract An approach to reducing and preventing surgical site infections (SSI) is to incorporate an antimicrobial compound into the formulation of medical adhesives. Previous work showed that two ceragenin compounds, CSA-44 and CSA-131, did not negatively affect the shear strength of an adhesive formulation, with the CSA-131 formulation showing an increase in shear strength. This work investigates the chemical basis for these effects by including in the adhesive formulations two other compounds similar to CSA-44 and CSA-131, nOC and nDC, respectively, that had the amine side chains removed. All formulations were evaluated by both shear and tensile testing to simulate the peeling motion associated with removing an adhesive bandage from skin. Shear strength was more sensitive to the molecular structure of the additive, with all additives increasing the shear strength of the formulation, whereas tensile strength was generally more consistent regardless of additive. The most significant structure that appears to affect the adhesive performance is the length of the aliphatic side chain; however, protonation of the shorter amine side chains may also play a role. Raman spectroscopy suggests the additives do not chemically modify the adhesive matrix. Ceragenin and related compounds should continue to be investigated as possible additives to medical adhesive formulations to reduce the incidence of SSI and improve patient outcomes. |
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| ISSN: | 3004-9261 |