Shikonin promotes ferroptosis though NSUN2-mediated m5C methylation modification of TFRC in acute myelocytic leukemia

Shikonin promotes ferroptosis though NSUN2-mediated m5C methylation modification of TFRC in acute myelocytic leukemia

Shikonin (SHK), extracted from the traditional Chinese herb Lithospermum erythrorhizon, demonstrates a wide range of pharmacological activities. This study aimed to explore the role and underlying mechanisms of the 5-methylcytosine (m5C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 in acute my...

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Bibliographic Details
Main Authors: Shuyu Chen, Yiqun Huang, Yinhao Liu, Liuxuan Jiang, Yuqing Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Hematology
Subjects:
Acute myelocytic leukemia
m5C
NSUN2
TFRC
ferroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2025.2495221
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