Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018
Abstract Background Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are intimately connected. A recently developed measure called Life’s Essential 8 (LE8) is used to evaluate cardiovascular health (CVH). We aimed to investigate the relationship between LE8 and the preva...
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2025-08-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03783-x |
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| author | Kang Wang Chunyan Li Lijun He Xiaolong Chen |
| author_facet | Kang Wang Chunyan Li Lijun He Xiaolong Chen |
| author_sort | Kang Wang |
| collection | DOAJ |
| description | Abstract Background Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are intimately connected. A recently developed measure called Life’s Essential 8 (LE8) is used to evaluate cardiovascular health (CVH). We aimed to investigate the relationship between LE8 and the prevalence of COPD, and the association between LE8 and all-cause mortality in individuals with COPD. Methods The National Health and Nutrition Examination Survey (NHANES) 2005–2018 was the source of the data used in our investigation. The participants were divided into three groups according to their LE8 scores: low (< 50), moderate (50–79), and high (≥ 80) CVH. Weighted logistic regression models and restricted cubic spline (RCS) curves were used to examine the relationship between LE8 score and the prevalence of COPD. To determine whether the results were stable, we used subgroup and sensitivity analyses. Furthermore, we evaluated the association between LE8 and all-cause mortality in COPD patients using a weighted Cox regression analysis. Results Weighted logistic regression analysis of the fully adjusted model indicated that a higher LE8 score was associated with a lower prevalence of COPD (OR = 0.75; 95% CI, 0.71–0.79). The RCS curves showed a linear negative association between them. LE8 score was negatively correlated with the prevalence of COPD across all subgroups, and this negative correlation was significant in those younger than 60 years old. The sensitivity analysis’s results were consistent with the primary findings. Furthermore, weighted Cox regression analysis of the fully adjusted model showed that LE8 score was negatively associated with all-cause mortality in COPD patients (HR = 0.81, 95% CI = 0.74–0.89). Conclusions LE8 score was negatively associated not only with the prevalence of COPD, but also with all-cause mortality in patients with COPD. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-a79a04b6e7654943aba7582319bc5091 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-a79a04b6e7654943aba7582319bc50912025-08-24T11:05:59ZengBMCBMC Pulmonary Medicine1471-24662025-08-0125111210.1186/s12890-025-03783-xRelationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018Kang Wang0Chunyan Li1Lijun He2Xiaolong Chen3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Army Medical UniversityDepartment of Geriatrics and Special Services Medicine, The Second Affiliated Hospital of Army Medical UniversityDepartment of Ultrasound, The Second Affiliated Hospital of Army Medical UniversityDepartment of Geriatrics and Special Services Medicine, The Second Affiliated Hospital of Army Medical UniversityAbstract Background Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are intimately connected. A recently developed measure called Life’s Essential 8 (LE8) is used to evaluate cardiovascular health (CVH). We aimed to investigate the relationship between LE8 and the prevalence of COPD, and the association between LE8 and all-cause mortality in individuals with COPD. Methods The National Health and Nutrition Examination Survey (NHANES) 2005–2018 was the source of the data used in our investigation. The participants were divided into three groups according to their LE8 scores: low (< 50), moderate (50–79), and high (≥ 80) CVH. Weighted logistic regression models and restricted cubic spline (RCS) curves were used to examine the relationship between LE8 score and the prevalence of COPD. To determine whether the results were stable, we used subgroup and sensitivity analyses. Furthermore, we evaluated the association between LE8 and all-cause mortality in COPD patients using a weighted Cox regression analysis. Results Weighted logistic regression analysis of the fully adjusted model indicated that a higher LE8 score was associated with a lower prevalence of COPD (OR = 0.75; 95% CI, 0.71–0.79). The RCS curves showed a linear negative association between them. LE8 score was negatively correlated with the prevalence of COPD across all subgroups, and this negative correlation was significant in those younger than 60 years old. The sensitivity analysis’s results were consistent with the primary findings. Furthermore, weighted Cox regression analysis of the fully adjusted model showed that LE8 score was negatively associated with all-cause mortality in COPD patients (HR = 0.81, 95% CI = 0.74–0.89). Conclusions LE8 score was negatively associated not only with the prevalence of COPD, but also with all-cause mortality in patients with COPD. Clinical trial number Not applicable.https://doi.org/10.1186/s12890-025-03783-xNHANESCOPDLife’s essential 8Cardiovascular healthAll-cause mortality |
| spellingShingle | Kang Wang Chunyan Li Lijun He Xiaolong Chen Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 BMC Pulmonary Medicine NHANES COPD Life’s essential 8 Cardiovascular health All-cause mortality |
| title | Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 |
| title_full | Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 |
| title_fullStr | Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 |
| title_full_unstemmed | Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 |
| title_short | Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005–2018 |
| title_sort | relationship between cardiovascular health and copd andits impact on all cause mortality in patients with copd analyses of nhanes 2005 2018 |
| topic | NHANES COPD Life’s essential 8 Cardiovascular health All-cause mortality |
| url | https://doi.org/10.1186/s12890-025-03783-x |
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