Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals
This is the studyto investigate the correlation between macular cone density (MCD) and flicker electroretinogram (ERG) response in healthy eyes. In this exploratory study, 23 eyes from 12 healthy subjects were enrolled in this study. The fixed-luminance flicker full-field electroretinogram (ffERG) r...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2075-1729/15/5/694 |
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| author | S. Saeed Mohammadi Woong-Sun Yoo Negin Yavari Hassan Khojasteh Jafari Christopher Or Azadeh Mobasserian Vahid Bazojoo Amir Akhavanrezayat Dalia El Feky Osama Elaraby Jia-Horung Hung Cigdem Yasar Ankur Gupta Tanya Jain Battuya Ganbold Trung Ba Nguyen Anadi Khatri Zheng Xian Thng Diana Do Quan Dong Nguyen |
| author_facet | S. Saeed Mohammadi Woong-Sun Yoo Negin Yavari Hassan Khojasteh Jafari Christopher Or Azadeh Mobasserian Vahid Bazojoo Amir Akhavanrezayat Dalia El Feky Osama Elaraby Jia-Horung Hung Cigdem Yasar Ankur Gupta Tanya Jain Battuya Ganbold Trung Ba Nguyen Anadi Khatri Zheng Xian Thng Diana Do Quan Dong Nguyen |
| author_sort | S. Saeed Mohammadi |
| collection | DOAJ |
| description | This is the studyto investigate the correlation between macular cone density (MCD) and flicker electroretinogram (ERG) response in healthy eyes. In this exploratory study, 23 eyes from 12 healthy subjects were enrolled in this study. The fixed-luminance flicker full-field electroretinogram (ffERG) responses of the retina and MCDs at 24 locations were measured using the Diopsys<sup>®</sup> NOVA™ system and the rtx1 adaptive optics retinal camera, respectively. Regression analysis was employed to evaluate the correlations. The mean age of the subjects was 30 ± 3 years. The average magnitudes of the flicker response and phase response were 13.44 ± 4.88 μV and 332.63 ± 22.12°, respectively. The MCDs for all 24 locations were 15,043 ± 3511 cones/mm². Among all locations, regression analysis revealed a significant correlation only at one specific location (0, −4°) between cone density and both the mean magnitude and phase of the flicker response, with <i>p</i>-values of 0.005 and 0.004, respectively.In conclusion, we identified a significant correlation between MCD and ffERG responses at a specific retinal locus (0, −4°). This finding may be attributed to the distribution of different cone types throughout the retina and the possibility that various cone types may contribute differently to ERG. Further studies are required to investigate this finding. |
| format | Article |
| id | doaj-art-a798e03d2f2e4c8caf42c1108e41dcd6 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-a798e03d2f2e4c8caf42c1108e41dcd62025-08-20T02:33:50ZengMDPI AGLife2075-17292025-04-0115569410.3390/life15050694Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy IndividualsS. Saeed Mohammadi0Woong-Sun Yoo1Negin Yavari2Hassan Khojasteh Jafari3Christopher Or4Azadeh Mobasserian5Vahid Bazojoo6Amir Akhavanrezayat7Dalia El Feky8Osama Elaraby9Jia-Horung Hung10Cigdem Yasar11Ankur Gupta12Tanya Jain13Battuya Ganbold14Trung Ba Nguyen15Anadi Khatri16Zheng Xian Thng17Diana Do18Quan Dong Nguyen19Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USABascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USASpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USAThis is the studyto investigate the correlation between macular cone density (MCD) and flicker electroretinogram (ERG) response in healthy eyes. In this exploratory study, 23 eyes from 12 healthy subjects were enrolled in this study. The fixed-luminance flicker full-field electroretinogram (ffERG) responses of the retina and MCDs at 24 locations were measured using the Diopsys<sup>®</sup> NOVA™ system and the rtx1 adaptive optics retinal camera, respectively. Regression analysis was employed to evaluate the correlations. The mean age of the subjects was 30 ± 3 years. The average magnitudes of the flicker response and phase response were 13.44 ± 4.88 μV and 332.63 ± 22.12°, respectively. The MCDs for all 24 locations were 15,043 ± 3511 cones/mm². Among all locations, regression analysis revealed a significant correlation only at one specific location (0, −4°) between cone density and both the mean magnitude and phase of the flicker response, with <i>p</i>-values of 0.005 and 0.004, respectively.In conclusion, we identified a significant correlation between MCD and ffERG responses at a specific retinal locus (0, −4°). This finding may be attributed to the distribution of different cone types throughout the retina and the possibility that various cone types may contribute differently to ERG. Further studies are required to investigate this finding.https://www.mdpi.com/2075-1729/15/5/694fixed-luminance flicker full-field electroretinogrammacular cone densityadaptive optics |
| spellingShingle | S. Saeed Mohammadi Woong-Sun Yoo Negin Yavari Hassan Khojasteh Jafari Christopher Or Azadeh Mobasserian Vahid Bazojoo Amir Akhavanrezayat Dalia El Feky Osama Elaraby Jia-Horung Hung Cigdem Yasar Ankur Gupta Tanya Jain Battuya Ganbold Trung Ba Nguyen Anadi Khatri Zheng Xian Thng Diana Do Quan Dong Nguyen Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals Life fixed-luminance flicker full-field electroretinogram macular cone density adaptive optics |
| title | Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals |
| title_full | Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals |
| title_fullStr | Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals |
| title_full_unstemmed | Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals |
| title_short | Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals |
| title_sort | correlation between fixed luminance flicker full field electroretinogram response and macular cone density in healthy individuals |
| topic | fixed-luminance flicker full-field electroretinogram macular cone density adaptive optics |
| url | https://www.mdpi.com/2075-1729/15/5/694 |
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