microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome

Obesity is associated closely with the metabolic syndrome (MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Explori...

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Main Authors: Qian Ge, Sonia Brichard, Xu Yi, QiFu Li
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2014/987285
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author Qian Ge
Sonia Brichard
Xu Yi
QiFu Li
author_facet Qian Ge
Sonia Brichard
Xu Yi
QiFu Li
author_sort Qian Ge
collection DOAJ
description Obesity is associated closely with the metabolic syndrome (MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
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institution Kabale University
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publishDate 2014-01-01
publisher Wiley
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spelling doaj-art-a796d5eac00740afb68bd2c8be1051622025-02-03T01:01:44ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/987285987285microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic SyndromeQian Ge0Sonia Brichard1Xu Yi2QiFu Li3Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, University of Louvain, 1200 Brussels, BelgiumNeurology Unit, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing 400042, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaObesity is associated closely with the metabolic syndrome (MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.http://dx.doi.org/10.1155/2014/987285
spellingShingle Qian Ge
Sonia Brichard
Xu Yi
QiFu Li
microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
Journal of Immunology Research
title microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
title_full microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
title_fullStr microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
title_full_unstemmed microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
title_short microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
title_sort micrornas as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome
url http://dx.doi.org/10.1155/2014/987285
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