PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY
The aim of the study was the pharmacokinetic and pharmacogenetic analysis of analgetic efficacy and safety of transdermal fentanyl for cancer patients.Material and methods. A comprehensive search for journal articlespublished between 2012 and 2017 was carried out using PubMed, Scopus, Web of Science...
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| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2018-07-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/770 |
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| author | O. P. Bobrova Y. A. Dyhno N. A. Shnayder M. M. Petrova S. K. Zyryanov |
| author_facet | O. P. Bobrova Y. A. Dyhno N. A. Shnayder M. M. Petrova S. K. Zyryanov |
| author_sort | O. P. Bobrova |
| collection | DOAJ |
| description | The aim of the study was the pharmacokinetic and pharmacogenetic analysis of analgetic efficacy and safety of transdermal fentanyl for cancer patients.Material and methods. A comprehensive search for journal articlespublished between 2012 and 2017 was carried out using PubMed, Scopus, Web of Science, and E-library databases.Results. The analysis of the data showed that pharmacokinetic and pharmacogenetic factors can influence the interindividual variability of analgesic therapy with fentanyl TTC for cancer patients, predetermining phenotypic differences in the efficacy and safety of analgesia. Enforced polypharmacotherapy with the use of inducers or inhibitors of the CYP3A4 isoenzyme activity can significantly change the effectiveness of analgesic therapy and result in undesirable side effects of strong opioids. Contradictory data on the effect of some single nucleotide polymorphisms of metabolic genes, transport genes and mu-opioid receptor genes dictate the necessity of further studies in this field.Conclusion. To date, there is no single explanation for interindividual variability of analgesic therapy with fentanyl TTS. A comprehensive assessment of the pharmacokinetic and pharmacogenetic factors affecting the efficacy and safety of analgesic therapy with potent opioids is a tool of a personalized approach for anesthesia in clinical oncology. |
| format | Article |
| id | doaj-art-a78a77beb8744a94beabc3d6caa8c516 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2018-07-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-a78a77beb8744a94beabc3d6caa8c5162025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-07-011739410010.21294/1814-4861-2018-17-3-94-100551PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGYO. P. Bobrova0Y. A. Dyhno1N. A. Shnayder2M. M. Petrova3S. K. Zyryanov4Krasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky of the Ministry of Health of Russia Krasnoyarsk Regional Clinical Oncology Center A.I. KryzhanovskyKrasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky of the Ministry of Health of Russia Krasnoyarsk Regional Clinical Oncology Center A.I. KryzhanovskyKrasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky of the Ministry of Health of RussiaKrasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky of the Ministry of Health of RussiaPeoples’ Friendship University of RussiaThe aim of the study was the pharmacokinetic and pharmacogenetic analysis of analgetic efficacy and safety of transdermal fentanyl for cancer patients.Material and methods. A comprehensive search for journal articlespublished between 2012 and 2017 was carried out using PubMed, Scopus, Web of Science, and E-library databases.Results. The analysis of the data showed that pharmacokinetic and pharmacogenetic factors can influence the interindividual variability of analgesic therapy with fentanyl TTC for cancer patients, predetermining phenotypic differences in the efficacy and safety of analgesia. Enforced polypharmacotherapy with the use of inducers or inhibitors of the CYP3A4 isoenzyme activity can significantly change the effectiveness of analgesic therapy and result in undesirable side effects of strong opioids. Contradictory data on the effect of some single nucleotide polymorphisms of metabolic genes, transport genes and mu-opioid receptor genes dictate the necessity of further studies in this field.Conclusion. To date, there is no single explanation for interindividual variability of analgesic therapy with fentanyl TTS. A comprehensive assessment of the pharmacokinetic and pharmacogenetic factors affecting the efficacy and safety of analgesic therapy with potent opioids is a tool of a personalized approach for anesthesia in clinical oncology.https://www.siboncoj.ru/jour/article/view/770fentanyl ttspharmacokineticspharmacogeneticschronic pain syndromeoncologypersonalizationliterature review |
| spellingShingle | O. P. Bobrova Y. A. Dyhno N. A. Shnayder M. M. Petrova S. K. Zyryanov PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY Сибирский онкологический журнал fentanyl tts pharmacokinetics pharmacogenetics chronic pain syndrome oncology personalization literature review |
| title | PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY |
| title_full | PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY |
| title_fullStr | PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY |
| title_full_unstemmed | PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY |
| title_short | PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY |
| title_sort | pharmacokinetic and pharmacogenetic aspects of personalized analgetic therapy with fentanil tts in clinical oncology |
| topic | fentanyl tts pharmacokinetics pharmacogenetics chronic pain syndrome oncology personalization literature review |
| url | https://www.siboncoj.ru/jour/article/view/770 |
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