Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma
Objective: to study the impact of the processes of lipid peroxidation (LPO) and antioxidant defense (AOD) on consciousness recovery trends in puerperas with eclampic coma. Subjects and methods. Two patient groups were examined. Group 1 (control) comprised 12 puerperas delivered by elective cesarean...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-10-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/385 |
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| author | I. Kh. Khapiy Yu. S. Podolsky |
| author_facet | I. Kh. Khapiy Yu. S. Podolsky |
| author_sort | I. Kh. Khapiy |
| collection | DOAJ |
| description | Objective: to study the impact of the processes of lipid peroxidation (LPO) and antioxidant defense (AOD) on consciousness recovery trends in puerperas with eclampic coma. Subjects and methods. Two patient groups were examined. Group 1 (control) comprised 12 puerperas delivered by elective cesarean section; Group 2 included 26 puerperas with eclampic coma, delivered by emergency cesarean section. To evaluate the efficacy of cytoflavin in leveling oxidative stress, Group 2 was divided into 2 subgroups: 2a) non-cytoflavin and 2b) cytoflavin. Investigations were made in the puerperas with eclampic coma at four stages: 1) on admission (on days 1—2 after the first convulsive attack); 2) on days 2—3 after admission); 3) during emergence from coma state; 4) before transition from an intensive care unit. Results. Comparison of the results obtained in two groups suggests that the eclampic coma puerperas showing a significant increase in lipid peroxides in the presence of AOD exhaustion have uncompensated oxidative stress. Comparative assessment of subgroups 2a and 2b established that incorporation of cytoflavin into the complex therapy of puerperas reduced the duration of coma. Conclusion. The use of cytoflavin results in a rapider normalization of LPO and an enhancement of AOD in puerperas with coma, which contributes to an earlier emergence from coma. Key words: eclampic coma, lipid peroxidation, antioxidant defense, consciousness recovery, cytoflavin. |
| format | Article |
| id | doaj-art-a789d0a08c044c73adbab9692c7e6c7d |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2010-10-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-a789d0a08c044c73adbab9692c7e6c7d2025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-10-016510.15360/1813-9779-2010-5-17385Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic ComaI. Kh. KhapiyYu. S. PodolskyObjective: to study the impact of the processes of lipid peroxidation (LPO) and antioxidant defense (AOD) on consciousness recovery trends in puerperas with eclampic coma. Subjects and methods. Two patient groups were examined. Group 1 (control) comprised 12 puerperas delivered by elective cesarean section; Group 2 included 26 puerperas with eclampic coma, delivered by emergency cesarean section. To evaluate the efficacy of cytoflavin in leveling oxidative stress, Group 2 was divided into 2 subgroups: 2a) non-cytoflavin and 2b) cytoflavin. Investigations were made in the puerperas with eclampic coma at four stages: 1) on admission (on days 1—2 after the first convulsive attack); 2) on days 2—3 after admission); 3) during emergence from coma state; 4) before transition from an intensive care unit. Results. Comparison of the results obtained in two groups suggests that the eclampic coma puerperas showing a significant increase in lipid peroxides in the presence of AOD exhaustion have uncompensated oxidative stress. Comparative assessment of subgroups 2a and 2b established that incorporation of cytoflavin into the complex therapy of puerperas reduced the duration of coma. Conclusion. The use of cytoflavin results in a rapider normalization of LPO and an enhancement of AOD in puerperas with coma, which contributes to an earlier emergence from coma. Key words: eclampic coma, lipid peroxidation, antioxidant defense, consciousness recovery, cytoflavin.https://www.reanimatology.com/rmt/article/view/385 |
| spellingShingle | I. Kh. Khapiy Yu. S. Podolsky Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma Общая реаниматология |
| title | Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma |
| title_full | Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma |
| title_fullStr | Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma |
| title_full_unstemmed | Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma |
| title_short | Trends in the Processes of Lipid Peroxidation and Antioxidant Defense in Puerperas with Eclampic Coma |
| title_sort | trends in the processes of lipid peroxidation and antioxidant defense in puerperas with eclampic coma |
| url | https://www.reanimatology.com/rmt/article/view/385 |
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