The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci

The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci

Abstract Monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in peripheral inflammation, has been shown to modulate established Alzheimer’s disease (AD) loci. In this study, we hypothesized that blood MCP-1 levels may impact the associations of other genetic variants with AD risk beyond...

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Main Authors: Jinghan Huang, Yixuan Wang, Thor D. Stein, Ting Fang Alvin Ang, Yibo Zhu, Qiushan Tao, Kathryn L. Lunetta, Jesse Mez, Rhoda Au, Lindsay A. Farrer, Wei Qiao Qiu, Xiaoling Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03542-w
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