Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study
Objective. To investigate the association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD). Methods. Data from 2051 participants who underwent 13C urea breath test and abdominal ultrasound examinations was collected. Participants were allocated to NAFLD...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/8040262 |
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| _version_ | 1849395751471284224 |
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| author | Ou Cai Zhenpeng Huang Ming Li Chaoqun Zhang Fengbo Xi Shiyun Tan |
| author_facet | Ou Cai Zhenpeng Huang Ming Li Chaoqun Zhang Fengbo Xi Shiyun Tan |
| author_sort | Ou Cai |
| collection | DOAJ |
| description | Objective. To investigate the association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD). Methods. Data from 2051 participants who underwent 13C urea breath test and abdominal ultrasound examinations was collected. Participants were allocated to NAFLD risk group and NAFLD nonrisk group based on definite risk factors for NAFLD. The relationship between H. pylori infection and NAFLD was analyzed. Results. No significant difference was found between rates of H. pylori infection and NAFLD using the chi-square test (P=0.30) or regression analysis (P=0.70). There was no significant difference between rates of H. pylori infection with and without NAFLD (P=0.47) in the NAFLD risk group or in the NAFLD nonrisk group (P=0.59). There was no significant difference between rates of H. pylori infection in men (P=0.69) and in women (P=0.27) or in participants aged 18–40 years (P=0.43), 41–65 years (P=0.14), and ≥66 years (P=0.66) with and without NAFLD in the NAFLD risk group or between the same sex or age groups (P=0.82, P=0.66, P=0.24, P=0.53, and P=1.00, resp.) in the NAFLD nonrisk group. Conclusions. H. pylori infection does not appear to increase the NAFLD prevalence rate or to be associated with, or a risk factor for, NAFLD. |
| format | Article |
| id | doaj-art-a7844cb315524e7cab4b78ddc0a16e82 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a7844cb315524e7cab4b78ddc0a16e822025-08-20T03:39:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/80402628040262Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical StudyOu Cai0Zhenpeng Huang1Ming Li2Chaoqun Zhang3Fengbo Xi4Shiyun Tan5Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaTeaching and Research Section of Internal Medicine, College of Clinical Medicine, Xi’an Medical University, Xi’an, Shannxi, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaEnshi Prefecture Center for Disease Control and Prevention, Enshi, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaObjective. To investigate the association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD). Methods. Data from 2051 participants who underwent 13C urea breath test and abdominal ultrasound examinations was collected. Participants were allocated to NAFLD risk group and NAFLD nonrisk group based on definite risk factors for NAFLD. The relationship between H. pylori infection and NAFLD was analyzed. Results. No significant difference was found between rates of H. pylori infection and NAFLD using the chi-square test (P=0.30) or regression analysis (P=0.70). There was no significant difference between rates of H. pylori infection with and without NAFLD (P=0.47) in the NAFLD risk group or in the NAFLD nonrisk group (P=0.59). There was no significant difference between rates of H. pylori infection in men (P=0.69) and in women (P=0.27) or in participants aged 18–40 years (P=0.43), 41–65 years (P=0.14), and ≥66 years (P=0.66) with and without NAFLD in the NAFLD risk group or between the same sex or age groups (P=0.82, P=0.66, P=0.24, P=0.53, and P=1.00, resp.) in the NAFLD nonrisk group. Conclusions. H. pylori infection does not appear to increase the NAFLD prevalence rate or to be associated with, or a risk factor for, NAFLD.http://dx.doi.org/10.1155/2018/8040262 |
| spellingShingle | Ou Cai Zhenpeng Huang Ming Li Chaoqun Zhang Fengbo Xi Shiyun Tan Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study Gastroenterology Research and Practice |
| title | Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study |
| title_full | Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study |
| title_fullStr | Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study |
| title_full_unstemmed | Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study |
| title_short | Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study |
| title_sort | association between helicobacter pylori infection and nonalcoholic fatty liver disease a single center clinical study |
| url | http://dx.doi.org/10.1155/2018/8040262 |
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