Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sheep

Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sheep

BackgroundIncreasing evidence indicated resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) regulated several biological processes via modulating gene expression. This study employed transcriptomic and metabolomic analyses to investigate the impact of RES and HMB supplementation, in combinati...

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Bibliographic Details
Main Authors: Yu Zhang, Kaina Zhu, Fengshuo Zhang, Zhenling Wu, Shengzhen Hou, Linsheng Gui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Nutrition
Subjects:
resveratrol
β-hydroxy-β-methylbutyric acid
Tibetan sheep
liver
transcriptome
metabolome
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1614114/full
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