Investigating the molecular mechanisms of the “Astragalus-Codonopsis” herb pair in treating diabetes: a network pharmacology and bioinformatics approach with molecular docking validation

Investigating the molecular mechanisms of the “Astragalus-Codonopsis” herb pair in treating diabetes: a network pharmacology and bioinformatics approach with molecular docking validation

Astragalus membranaceus and Codonopsis pilosula are widely used in traditional chinese medicine for the treatment of diabetes because of their notable hypoglycemic pharmacological effects. Studies have indicatedthat the active compounds in the Astragalus-Codonopsis herb pair may exert their hypoglyc...

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Bibliographic Details
Main Authors: Jinliang Yang, Mingyang Li, Ziyue Zhu, Fengling Han, Yanyan Ma, Jinbo Hou, Qingfeng Zhao, Hui Yuan, XiuMei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Astragalus-Codonopsis
network pharmacology
molecular dynamics
GSK3 β
insulin resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1618575/full
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